|Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|Outline of Final Research Achievements
Intravenous (iv) injection of propofol and inhalational anesthesia sevoflurane dose-dependently inhibited the single unit activity (SUA) of the OX cell in the perifornical hypothalamus (PFH) and lateral hypothalamus (LH). These inhibitory effect of propofol and sevoflurane were blocked by GABA-receptor antagonist, gabazine. NMDA antagonist, ketamine and α2 receptor antagonist, dexmedetomidine did not affect OX cell activity in the LH and PFH.