| Project/Area Number |
18591672
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
KITANO Toshio Osaka City University, Graduate School of Medicine, Visiting associate professor (50291597)
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| Co-Investigator(Kenkyū-buntansha) |
TERAI Tomihide Osaka City University, Graduate School of Medicine, Lecturer (20382046)
NOMURA Chizumi Osaka City University, Graduate School of Medicine, Resercher (10382227)
HASHIMOTO Yusuke Osaka City University, Graduate School of Medicine, Assistant (10382178)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,560,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | DDS / Articular cartilage / Liposome / Joint lubrication / Intra-artuicular injection / in-vivo / リポソーム化 / in-vivo実験 / ヒアルロン酸ナトリウム / 変形性関節症 / 治療薬 / 変性関節軟骨 / 軟骨欠損 / 関節形成術 / 内包率 |
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| Research Abstract |
The purpose of this study is to clarify the effect of new drug delivery system(DDS) in vivo study. This new DDS is liposome build of Lα-dipalmitoylphosphatidylcholine (DPPC) include Hyaluronic acid which would improve the joint lubrication and restore the degenerative or damaged articular cartilage.
Using rabbit's knee joint, our new DDS was injected into the knee joint. One, seven and fourteen days after injection, Concentration of the joint effusion was measured and inflammation sign of synovium and cartilage were inspected.
Concentration of the joint effusion the new DDS injected was two times as that of control. Inflammation sign of synovium and cartilage were not observed in any specimen.
The result of this study is one of the biggest steps to use this for the clinical therapy.
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