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Development of a polarization transfer system for PHIP method

Research Project

Project/Area Number 18K03679
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 15020:Experimental studies related to particle-, nuclear-, cosmic ray and astro-physics
Research InstitutionWakayama Medical University

Principal Investigator

Fujimura Hisako  和歌山県立医科大学, 医学部, 准教授 (90378589)

Co-Investigator(Kenkyū-buntansha) 牧野 誠司  和歌山県立医科大学, 医学部, 教授 (70222289)
田中 正義  神戸常盤大学, 保健科学部, その他 (70071397)
Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsPHIP法 / 超偏極 / 19F-NMR / フッ素19 / パラ水素 / PHIP / 19F
Outline of Final Research Achievements

We studied to produce hyperpolarized 19F compounds as MRI contrast agents for hyperpolarized MRI. Using 3,3,4,4,5,5,6,6,6-nonafluoro-1-hexene as a 19F compound, we investigated catalysts and conditions that efficiently promote the hydrogenation reaction by measuring 19F-NMR. In this study, the hydrogenation reaction took several hours, and it was found that increasing the hydrogen pressure was an effective factor in accelerating the reaction rate. In the parahydrogen induced polarization (PHIP) method, the hydrogenation reaction needs to proceed in a short time not to take depolarization. Therefore, we are currently investigating the construction of a system that can handle several atmospheres of hydrogen gas.

Academic Significance and Societal Importance of the Research Achievements

超偏極した13C,3He,19Fなどの原子核を造影剤として利用するMRI(超偏極MRI)は,検査被ばくのない画像診断装置として期待されている。特に19Fは体内にほとんど存在しないためバックグラウンドが少ない利点があり,PHIP法を用いると安価で簡便に超偏極核生成が可能となる。また,1Hと共鳴周波数が近いため,既存の医療用MRIを利用することが可能となることも,広く医療で利用するために重要である。本研究は,PHIP法を用いて効率的に19F化合物を超偏極させる技術の確立を目的としており,超偏極MRIの造影剤の基礎研究に位置づけられる。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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