| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Tenacibaculum maritimum is the causative agent of tenacibaculosis, which affects a large number of marine fish species and is characterized by fin and mouse erosion, and necrotic ulcers of skin. In Japan, there is no available licensed tenacibaculosis vaccine for cultured fish. Use of medicine for this disease is limited. To develop tenacibaculosis vaccine, we focused on adhesins and phage receptors of T. maritimum, because those molecules exist on bacterial cell surface and thus can be easily recognized by fish immune system. We analyzed T. maritimum mutants showing abnormal gliding motility by next-generation sequencer, and also analyzed T. maritimum-specific phages.
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