Non-invasive estimation of human iron load and its clinical application using T2* and T2 maps calculated from MR imaging
| Project/Area Number |
19591424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Fukuoka University (2008-2009)
Kyushu University (2007) |
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Principal Investigator |
YOSHIMITSU Kengo Fukuoka University, 医学部, 教授 (20274467)
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Hiroshi 九州大学, 医学研究院, 教授 (90145433)
IRIE Hiroyuki 九州大学, 病院, 講師 (50284493)
TAJIMA Tsuyoshi 九州大学, 病院, 助教 (50346798)
NISHIE Akihiro 九州大学, 病院, 助教 (20457427)
HIRAKAWA Masakazu 九州大学, 医学研究院, 学術研究長 (20380454)
ISHIGAMI Kousei 九州大学, 病院, 助手 (10403916)
USHIJIMA Yasuhiro 九州大学, 病院, 助手 (40432934)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肝 / 鉄代謝 / T2*値 / T2値 / 脾 / T2^*値 |
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| Research Abstract |
Newly developed T2* and T2 maps were clinically applied to patients with chronic liver diseases. As liver dysfunction progresses, T2* and T2 values of the liver decreased, representing intrinsic iron deposit. After SPIO, ΔT2*and ΔT2 also reduced, representing Kupffer cell dysfunction. Splenic signals were also correlated to liver dysfunction level. T2* and T2 maps were useful in assessing hepatosplenic condition in patients with chronic liver disease.
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Report
(4 results)
Research Products
(11 results)
