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Mechnism of gastric cancer heterogeneity by comprehensive genetic analysis of clinical specimens

Research Project

Project/Area Number 19K08448
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionYokohama City University

Principal Investigator

SHIBATA Wataru  横浜市立大学, 医学研究科, 客員准教授 (00435819)

Co-Investigator(Kenkyū-buntansha) 金子 裕明  横浜市立大学, 医学部, 助教 (20760078)
前田 愼  横浜市立大学, 医学研究科, 教授 (40415956)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords胃癌 / 未分化癌 / 分化型癌 / 混在癌 / 不均一性
Outline of Research at the Start

胃癌は世界で年間70万人が死亡する癌であり、特に日本ではその罹患率が高く、毎年約5万人が胃癌で死亡している。胃癌の進行と癌の組織学的不均一性には大きな関連があることが推測され、その獲得メカニズムを明らかにすることは、胃癌進展を抑制する対策となりうると考えられる。本研究における胃癌における不均一性とは分化型胃癌において未分化型成分が混在してくると仮説を立て、検証を行う。まず、早期胃癌内視鏡切除検体における臨床病理学的検討を行う。胃癌臨床検体異種移植モデルによる腫瘍細胞バンクの構築を行う。さらに、臨床検体、細胞を用いて、ゲノムエピゲノム解析を行うことにより、その不均一性のメカニズムを解析する。

Outline of Final Research Achievements

Most early-stage gastric cancers are purely differentiated cancers, but advanced cancers contain undifferentiated components, and it is thought that the cancer changes from differentiated cancers to undifferentiated cancers as it progresses. On the other hand, there are cases of early stage cancer with only undifferentiated components. In the clinicopathological examination of undifferentiated mixed early stage cancer, the tumor diameter was slightly larger (16.1 mm vs 24.4 mm) and SM invasive cancer was more common (12.2% vs 45.7%). Staining of E-cadherin as a marker for undifferentiated tissue was deficient in cancer cells in many purely undifferentiated cases, but the expression was decreased in mixed cases, but there were few cases in which it was deficient. rice field. It was suggested that there are different pathways for the development of undifferentiated cancer in gastric cancer.

Academic Significance and Societal Importance of the Research Achievements

胃癌の不均一性は胃癌の進行と関連しており、早期癌においても予後不良の因子と考えられている。本研究では早期胃癌においても、未分化成分の混在がその深部浸潤と関連する可能性を示した。また、未分化成分の出現には、分化型から発生するものと、未分化型として発生する経路があり、進行癌における治療法の選択にも考慮が必要である可能性が示唆された。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (2 results)

All 2022

All Journal Article (2 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] The Origin of Epithelium with Low-Grade Atypia in Early Gastric Cancer2022

    • Author(s)
      Yamada Hiroaki、Kaneko Hiroaki、Kuwashima Hirofumi、Sugimori Makoto、Tsuyuki Sho、Sanga Katsuyuki、Irie Kuniyasu、Sasaki Tomohiko、Kondo Masaaki、Miyake Akio、Maeda Shin
    • Journal Title

      Digestion

      Volume: 103 Issue: 3 Pages: 217-223

    • DOI

      10.1159/000521875

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of gastric endoscopic submucosal dissection in elderly patients aged ? 80 years2022

    • Author(s)
      Inokuchi Yasuhiro、Ishida Ayaka、Hayashi Kei、Kaneta Yoshihiro、Watanabe Hayato、Kano Kazuki、Furuta Mitsuhiro、Takahashi Kosuke、Fujikawa Hirohito、Yamada Takanobu、Yamamoto Kouji、Machida Nozomu、Ogata Takashi、Oshima Takashi、Maeda Shin
    • Journal Title

      World Journal of Gastrointestinal Endoscopy

      Volume: 14 Issue: 1 Pages: 49-62

    • DOI

      10.4253/wjge.v14.i1.49

    • Related Report
      2021 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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