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Discrimination of social reward inequalities in rats

Research Project

Project/Area Number 19K22475
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 46:Neuroscience and related fields
Research InstitutionJichi Medical University

Principal Investigator

Onaka Tatsushi  自治医科大学, 医学部, 教授 (90177254)

Project Period (FY) 2019-06-28 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords愛着様行動 / 羨望 / 社会的報酬 / 超音波発声 / オキシトシン受容体 / 条件付け場所嗜好性試験 / 接触刺激 / 発声
Outline of Research at the Start

ヒトは、他個体が自分よりもいい思いをしているときに羨望を感じ不快に思う。この社会的感情は、不平等嫌悪に関わる感情の一つと考えられる。また、自分と特別な絆関係にあるヒトが別のヒトに愛情を注ぐのを見ると嫉妬を感じる。不平等を嫌い公平性を好む羨望感情、さらに特定の相手との排他的な関係性を求める嫉妬感情は、社会的規範・道徳性の起源に繋がる感情と考えられる。こういった感情がどの程度生得的で生物学的基盤をもつのか明らかでない。本研究は、ペット化したラットを用いた動物実験モデルを構築しその神経回路の解明に繋げる。

Outline of Final Research Achievements

After receiving stroking stimuli repetitively from an early age, rats exhibit pet-like behaviors, such as distinguishing and following the human who have petted them. Using this animal model, we examined whether rats can discriminate inequality in social rewards. In this model, interaction with a familiar experimenter was used as a social reward. In the present study, rats received repeated stroking stimuli after weaning. In a social inequality condition, only other individuals received stroking stimuli in front of them. Rats emitted a special type of ultrasonic vocalizations in this situation while rats emitted 50 kHz calls, indicative of the appetitive state, with an affiliative human in front of them. All these data suggest that rats could discriminate social inequality conditions. Experiments with an oxytocin receptor antagonist suggested that the oxytocin receptor is not essential for expression of affiliative behaviors.

Academic Significance and Societal Importance of the Research Achievements

不平等を嫌う感情や特定の相手との排他的関係を求める嫉妬感情は社会的規範・道徳性の起源に繋がる感情と考えられ、社会を構築するのに基盤的な社会的情動である。しかし、羨望・嫉妬の感情がどの程度生得的で生物学的基盤をもつものなのか、あるいは、社会的文化的に形成されるものかは分かっていなかった。本研究により集団生活を行う齧歯動物において社会的報酬の不平等を識別することが明らかとなり、その生物学的基盤を探求する道が開けた。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (13 results)

All 2023 2022 2021 2020 2019

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 8 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Novel 31-kHz calls emitted by female Lewis rats during social isolation and social inequality conditions.2023

    • Author(s)
      Okabe S, Takayanagi Y, Yoshida M, Onaka T.
    • Journal Title

      iScience

      Volume: 26 Issue: 3 Pages: 106243-106243

    • DOI

      10.1016/j.isci.2023.106243

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Indispensable role of the oxytocin receptor for allogrooming toward socially distressed cage mates in female mice2021

    • Author(s)
      Matsumoto Makiya、Yoshida Masahide、Jayathilake Buddhini Wimarsha、Inutsuka Ayumu、Nishimori Katsuhiko、Takayanagi Yuki、Onaka Tatsushi
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 33 Issue: 6 Pages: 1-17

    • DOI

      10.1111/jne.12980

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of Oxytocin in Stress Responses, Allostasis and Resilience2021

    • Author(s)
      Takayanagi Yuki、Onaka Tatsushi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 1 Pages: 150-150

    • DOI

      10.3390/ijms23010150

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The oxytocin system and early‐life experience‐dependent plastic changes2021

    • Author(s)
      Onaka Tatsushi、Takayanagi Yuki
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 33 Issue: 11

    • DOI

      10.1111/jne.13049

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Post-weaning stroking stimuli induce affiliative behavior toward humans and influence brain activity in female rats2021

    • Author(s)
      Okabe S, Takayanagi Y, Yoshida M, Onaka T.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 3805-3805

    • DOI

      10.1038/s41598-021-83314-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of neuropeptides in vivo and open questions for current and upcoming fluorescent sensors for neuropeptides2021

    • Author(s)
      Inutsuka Ayumu、Ino Daisuke、Onaka Tatsushi
    • Journal Title

      Peptides

      Volume: 136 Pages: 170456-170456

    • DOI

      10.1016/j.peptides.2020.170456

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gentle stroking stimuli induce affiliative responsiveness to humans in male rats.2020

    • Author(s)
      Shota Okabe, Yuki Takayanagi, Masahide Yoshida & Tatsushi Onaka
    • Journal Title

      Scientific Reports

      Volume: in press Issue: 1 Pages: 9135-9135

    • DOI

      10.1038/s41598-020-66078-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualization of a blue light transmission area in living animals using light-induced nuclear translocation of fluorescent proteins2020

    • Author(s)
      Inutsuka Ayumu、Kimizuka Norihiro、Takanohashi Natsuki、Yakabu Hisashi、Onaka Tatsushi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 522 Issue: 1 Pages: 138-143

    • DOI

      10.1016/j.bbrc.2019.11.023

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 他者との親和的関係性構築の研究から見出されたラットの新規超音波発声オキシトシンニューロンの賦活化2023

    • Author(s)
      岡部祥太, 高柳友紀, 吉田匡秀, 尾仲達史
    • Organizer
      第32回バソプレシン・オキシトシン研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] A novel ultrasonic vocalization emitted by rats during social inequality condition.2022

    • Author(s)
      Shota Okabe, Yuki Takayanagi, Masahide Yoshida, Tatsushi Onaka
    • Organizer
      第82回日本動物心理学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 思春期接触刺激と愛着形成2022

    • Author(s)
      尾仲達史、岡部祥太、高柳友紀、吉田匡秀
    • Organizer
      第127回日本解剖学会総会・全国学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 他個体に対する毛繕い行動中のオキシトシン受容体発現細胞の活性化2019

    • Author(s)
      松本まきや、吉田匡秀、岡部祥太、犬束歩、高柳友紀、尾仲達史
    • Organizer
      日本行動神経内分泌研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Diverse actions of oxytocin in the control of social behaviors under stressful conditions.2019

    • Author(s)
      Onaka T
    • Organizer
      The 5th Meeting of the Japan Branch of International Neuropeptide Society International Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2019-07-04   Modified: 2024-01-30  

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