Structural characterization of supramolecular nucleic acid structure based on IR vibrational spectroscopy and quantum chemical calculation
Project/Area Number |
20350012
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Physical chemistry
|
Research Institution | Yokohama City University |
Principal Investigator |
SAIGUSA Hiroyuki Yokohama City University, 大学院・生命ナノシステム科学研究科, 教授 (90162180)
|
Co-Investigator(Kenkyū-buntansha) |
TACHIKAWA MASANORI 横浜市立大学, 生命ナノシステム科学研究科, 教授 (00267410)
OHBA MASASHI 横浜薬科大学, 薬学部, 教授 (60115219)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
|
Keywords | クラスター / 核酸塩基 / 赤外振動スペクトル / 塩基ヌクレオチド / レーザー脱離 / 非調和振動計算 / 修飾塩基 / 量子化学計算 / 化学修飾 |
Research Abstract |
We have developed laser desorption technique for generating hydrated clusters of the DNA base pairs and those of nucleoside molecules consisting of base and sugar group, and performed structural characterization based on UV and IR spectroscopy combined with quantum mechanical calculation. We have also implemented this method for vaporizing a nucleotide having sugar-phosphate backbone, and identified the formation of a supramolecular structure.
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Report
(4 results)
Research Products
(57 results)