Approach to Molecular Development of the Drug that induces Mitotic Catastrophe in Cancer cells
Project/Area Number |
20590391
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
|
Research Institution | Hokkaido University |
Principal Investigator |
TAKIMOTO Masato 北海道大学, 遺伝子病制御研究所, 准教授 (30179585)
|
Co-Investigator(Kenkyū-buntansha) |
OCHIYA Takahiro 国立がんセンター研究所, 分子細胞治療研究分野, 分野長 (60192530)
|
Project Period (FY) |
2008 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 分裂破局死 / D40 / がん / 細胞死 / 増殖抑制 / RNA干渉 / p53 / D40siRNA / がん細胞 / p53 nul 細胞 / D40,癌 / 分子創薬 / 癌細胞 / 分子標的 |
Research Abstract |
Synthetic double-stranded RNA specific to D40 gene (D40 siRNA) human cancer cell lines. D40 siRNA caused a p53 independent cell death "Mitotic Catastrophe". Further D40 siRNA treatment to tumor-burden experimental animals induced inhibitions of the tumor growth. The molecular therapy targeting to D40 protein is encouraging in human cancer treatment in future.
|
Report
(6 results)
Research Products
(26 results)