Identification of novel genes related with stem cell and cancer stem cell in the transdifferentiation to gastric intestinal mataplasia.

Research Project

Project/Area Number	20590716
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Gastroenterology
Research Institution	Tohoku University
Principal Investigator	IMATANI Akira Tohoku University, 病院, 講師 (30333876)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	胃 / 分化制御 / 幹細胞 / 癌 / 発生・分化 / 発現制御 / シグナル伝達
Research Abstract	The transdifferentiation to intestinal metaplasia is considered as a gastric carcinogenesis sequence in H.pylori infection. Down-regulation of a homeobox gene Sox2 might contribute to the gastric carcinogenesis in this manner. We established an in vitro model of this transdifferentiation by down-regulation of Sox2, and identified a pseudokinase gene Tribbles using Microarray analyses. This gene overexpressed in the human gastric cancer tissues and cell lines.

Report

(4 results)