Substrates and upstream approaches to atrial fibrillation
Project/Area Number |
20590839
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Keio University |
Principal Investigator |
SHIROSHITA Akiko Keio University, 医学部, 助教 (40276241)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 医学 / 循環器 / 心房細動 / 酸化ストレス / 循環器・高血圧 |
Research Abstract |
In this study, the authors evaluated the substrates and upstream approaches to atrial fibrillation by using canine atrial tachypacing model. Prolonged atrial tachypacing caused atrial electrical remodeling and atrial fibrillation promotion accompanying by increased oxidative stress marker. Carvedilol, a beta blocker with antioxidant and anti-inflammatory properties, significantly attenuated atrial remodeling and atrial fibrillation promotion by preventing the increase of oxidative stress marker.
|
Report
(4 results)
Research Products
(14 results)