The difference of nature and functional role between tumor-nest versus tumor-stroma infiltrating lymphocytes in oral cancer.

• Project/Area Number: 20592325
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: KATOU Fuminori Hamamatsu University School of Medicine, 医学部, 准教授 (60204492)
• Co-Investigator(Kenkyū-buntansha): WATANABE Yoshiko 浜松科大学, 医学部, 助教 (10444358)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 口腔癌 / リンパ球 / NK細胞 / 樹状細胞 / 活性化

Research Abstract

We identified the tumor-nest and tumor-stroma infiltrating lymphocytes, and examined their functional role and activation status. In the tumor nest inhibitory CD8+ CTLs were abundant, but in the tumor stroma they were scarce. On the contrary, activated CD8+ CTLs and CD4+ T cells plentifully infiltrated to the tumor stroma.

Research Products

• [Journal Article] Tumor-infiltrating lymphocytes, particularly the balance between CD8+ T cells and CCR4+ regulatory T cells, affect the survival of patients with oral squamous cell carcinoma. (2010)
  • Author(s): Watanabe Y, Katou F, Ohtani H, Nakayama T, Yoshie O, Hashimoto K
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109 Pages: 744-752
• [Journal Article] Eotaxin-3/CC chemokine ligand 26 is a functional ligand for CX3CR1 (2010)
  • Author(s): Nakayama T, Watanabe Y, Oiso N, Higuchi T, Shigeta A, Mizuguchi N, Katou F, Hashimoto K, Kawada A, Yoshie O
  • Journal Title: J Immunol Volume: 185 Pages: 6472-6479
  • Peer Reviewed
• [Journal Article] Tumor-infiltrating lymphocytes, particularly the balance between CD8+T cells and CCR4+ regulatory T cells, affect the survival of patients with oral squamous cell carcinoma (2010)
  • Author(s): Watanabe Y, Katou F, Ohtani H, Nakayama T, Yoshie O, Hashimoto K
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109 Pages: 744-752
  • Peer Reviewed
• [Presentation] 口腔扁平上皮癌に浸潤する制御性T細胞の密度は生命予後を規定する (2008)
  • Author(s): 渡邉賀子、加藤文度、田中秀生、増本一真、大浦健宏、内山佳之、薗田直志、長田哲次、橋本賢二
  • Organizer: 第53回日本口腔外科学会総会学術大会
  • Place of Presentation: 徳島
• [Remarks] ホームページ等