Analysis of the cytokine network in fracture site under conditions of osteoporosis
| Project/Area Number |
20592471
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
SATOH Tazuko The Nippon Dental University, 生命歯学部, 教授 (40095138)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUNO Tomonori 日本歯科大学, 生命歯学部, 准教授 (80199827)
OMATA Kazuhiko 日本歯科大学, 生命歯学部, 助教 (00434142)
SUZUKI Tetsuro 浜松医科大学, 感染症学講座, 教授 (00250184)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 老年歯科学 / 骨粗鬆症 / 骨粗鬆症モデルマウス / 脛骨骨折モデル / サイトカイン / マルチプルサイトカインアッセイ / サイトカインネットワーク / 酸化ストレス / 抗酸化度 |
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| Research Abstract |
The purpose of this study was to investigate the cytokine network in fracture under conditions of osteoporosis. Tibia fractures were made in ovariectomy mice, and analyzed cytokine expression using multiple cytokine assays. The results suggested that the delay of fracture healing may be related to the influence of cytokine receptors of osteoblasts or osteoclasts in osteoporosis.
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Report
(4 results)
Research Products
(3 results)
