Regulation of host-alternative splicing in herpesvirus-infected
| Project/Area Number |
20790353
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NOJIMA Takayuki Tokyo Medical and Dental University, 大学院・疾患生命科学研究部, 特任助教 (80431956)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 単純ヘルペスウイルス / 選択的スプライシング / 前骨髄球性白血病(PML)遺伝子 / ICP27 / Pre-Mrna / スプライシングアイソフォーム / ミニ遺伝子 / Pre-mRNA |
|---|
| Research Abstract |
Herpes simplex virus type-2 (HSV-2) is one of DNA viruses, which is spread world-wide and replicates own virus genome in host-cell nucleus. In this study, I examined how HSV-2 replicates own genome in the nucleus. Here I showed that HSV-2 virus protein interfered with the step of host mRNA processing. I further showed that this interference played important role of virus replication.
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Report
(3 results)
Research Products
(14 results)
