Cystatin C as a useful biomarker for cardiovascular disease and chronic kidney disease in obesity and cardio-renal interaction
Project/Area Number |
20790418
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Laboratory medicine
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Research Institution | Department of Clinical Research, National Hospital Organization Kyoto Medical Center |
Principal Investigator |
MAJIMA Takapumi Department of Clinical Research, National Hospital Organization Kyoto Medical Center, 臨床研究企画運営部, 研究員 (80470186)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 医療・福祉 / 内科 / 臨床 / 肥満症 / 慢性腎臓病 / 循環器・高血圧 / 糖尿病 / メタボリックシンドローム |
Research Abstract |
本研究は、肥満/メタボリック症候群(MetS)にて、血清・尿中シスタチンC(Cys-C)ともに尿中アルブミンと有意な相関を認め、尿中Cys-CはMetSの危険因子重積度や動脈硬化指標と有意な相関を認めた。減量治療や降圧薬・ARB投与により、腎糸球体・尿細管障害指標の中でも、特に尿中Cys-Cの有意な改善を認めた。以上より、肥満/MetSに伴うCKD進展に尿細管障害の関与も考えられ、Cys-Cは肥満・MetSのCKD及びCVDリスク指標として有用であることが示された。
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Effects of risedronate or alfacalcidol on bone mineral density, bone turnover, back pain, and fractures in Japanese men with primary osteoporosis: results of a two-year strict observational study.2009
Author(s)
Majima T, Shimatsu A, Komatsu Y, Satoh N, Fukao A, Ninomiya K, Matsumura T, Nakao K.
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Journal Title
J Bone Miner Metab 27
Pages: 168-174
Related Report
Peer Reviewed
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[Journal Article] Effects of risedronate or alfacalcidol on bone mineral density, bone turn over, back pain, and fractures in Japanese men with primary osteoporosis : results of a two-year strict observational study.2009
Author(s)
Majima T, Shimatsu A, Komatsu Y, Satoh N, Fukao A, Ninomiya K, Matsumura T, Nakao K.
-
Journal Title
J Bone Miner Metab 27
Pages: 168-174
Related Report
Peer Reviewed
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