Signaling mechanism and the role of HGF for radiation-induced liver damage

• Project/Area Number: 20790880
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: IMAEDA Masumi Gunma University, 医学部, 医員 (30451727)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 放射線照射後肝障害 / TGF-beta / 照射後肝障害 / TGF-ベータ

Research Abstract

In the control (0Gy) and 15Gy groups, all mice survived but 80% of the mice in the 30Gy group died 6 months after irradiation. TGF-beta expression was significantly induced from 1 day to 4 weeks in the 15Gy and 30Gy groups compared with the control and 5Gy groups. Plasma albumin was decreased immediately after liver irradiation but was gradually resolved 4 weeks after irradiation. Similarly, recovery from liver damage 4 weeks after 30Gy and 15Gy irradiation was observed using the immunohistochemical staining method but no liver fibrosis was detected. TGF-beta may predict radiation-induced liver damage and death from the damage without a close relationship with liver fibrosis.