The role of Th17 cell and IL-17 in the aggressive periotonditis
| Project/Area Number |
20791625
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Aichi Gakuin University |
|---|
Principal Investigator |
TANAKA Shigehisa Aichi Gakuin University, 歯学部, 講師 (30367619)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 歯周免疫機能学 / T細胞 / インターロイキン17 / 歯周病 / 歯学 / 免疫学 |
|---|
| Research Abstract |
GCF was gathered from the patient diagnosed aggressive periodontitis, and the IL-17 density was measured. But all samples were not detected. The result was similar though it had measured in consideration of the method of gathering GCF. To confirm the existence of IL-17 in the local of gingival, The expression of IL-17mRNA was recognized in gingiva with real-time PCR. Next, It was confirmed that the THP-1 cell produced IL-12 and IL-23 stimulated with LPS. The monocytes isolated from the peripheral blood stimulated with E.coli LPS.IL-12 and IL-23 was measured of in the culture supernatant. Though both cytokines were able to detected, there were no significant difference between the aggressive periodontitis patient and healthy group. It is necessary to be going to increase the number of samples in the future and to examine it.
|
Report
(3 results)
Research Products
(5 results)
