Molecular basis of immune homeostasis originating from the thymus
| Project/Area Number |
20H03464
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 49030:Experimental pathology-related
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| Research Institution | Chiba University |
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Principal Investigator |
KIMURA Motoko 千葉大学, 大学院医学研究院, 教授 (00345018)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2022: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2020: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 制御性T細胞 / CD69 / γδT細胞 / 胸腺 / 恒常性維持 / アゴニスト選択 |
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| Outline of Research at the Start |
制御性T（Treg）細胞をはじめとしたアゴニスト選択によって分化誘導される細胞群は、自己免疫疾患制御、生体の恒常性維持、がん免疫、各種炎症反応等に重要な働きをすることが知られているが、その分化機構、各種サブセットの存在、機能の詳細は不明点が多い。一方、CD69分子は、アゴニスト選択によって分化誘導される細胞群に恒常的に発現しており、その分化、機能に重要な働きをすることが示唆される。本申請研究では、「Treg細胞」「CD69」「胸腺内アゴニスト選択」という三つのキーワードに基づいて研究を進め、生体の恒常性維持機構と恒常性維持に重要な各種T細胞の分化機構と機能についての新規のメカニズム解析を行う。
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| Outline of Final Research Achievements |
Regulatory T cells and Innate-like T cells that are differentiated by the thymic agonist selection such as natural killer T cells and γδT cells, are known to play important roles in regulating autoimmune diseases, tissue homeostasis, cancer immunity, and various inflammatory responses. However, the details of their subsets, differentiation mechanisms, and functions remain unclear. In this study, we focused on the CD69 molecule, which has been known as an activation marker of leukocytes, and found that CD69 regulates the differentiation and function of the regulatory T cells and innate-like T cells. CD69 expressed by T cells was found to be involved in tissue homeostasis and anti-tumor immune responses.
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| Academic Significance and Societal Importance of the Research Achievements |
制御性T細胞や自然免疫型T細胞（NKT細胞、γδT細胞など）は、感染に対する免疫応答や抗腫瘍免疫応答に働くだけでなく、組織の恒常性維持に寄与することが明らかとなってきた。本研究では、CD69分子が、これらの細胞の分化・維持・機能を制御することを見出した。この事実は、将来的に、ヒトの炎症性疾患や腫瘍に対する新たな治療法開発に貢献できる可能性を示唆する。
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Increased Myosin light chain 9 expression during Kawasaki disease vasculitis2023
Author(s)
Kobayashi Hironobu、Kimura Motoko Y.、Hasegawa Ichita、Suganuma Eisuke、Ikehara Yuzuru、Azuma Kazuhiko、Ito Toshihiro、Ebata Ryota、Kurashima Yosuke、Kawasaki Yohei、Shiko Yuki、Saito Naoki、Iwase Hirotaro、Lee Youngho、Noval Rivas Magali、Arditi Moshe、Zuka Masahiko、Hamada Hiromichi、Nakayama Toshinori
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Journal Title
Frontiers in Immunology
Volume: 13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] CD69 regulates anti-tumor immunity2021
Author(s)
Kimura M., Nasu R., Mita Y., Wang Y., Endo Y., Hasegawa I., Motohashi S., Nakayama T.
Organizer
The 50th Annual Meeting of the Japanese Society for Immunology
Related Report
Int'l Joint Research / Invited
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[Presentation] CD69 Biology and Pathology2020
Author(s)
Kimura M.Y., Koyama-Nasu, R., Mita Y., Hayashizaki, K. and Nakayama T.
Organizer
11th International Symposium of IFReC, Immunology at the Forefront
Related Report
Int'l Joint Research / Invited
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