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Basic study for improving a nutritional condition using mental effect of eating

Research Project

Project/Area Number 20K23265
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0909:Sports sciences, physical education, health sciences, and related fields
Research InstitutionToyo University

Principal Investigator

Takatsuru Yusuke  東洋大学, 食環境科学部, 教授 (30446265)

Project Period (FY) 2020-09-11 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords食の嗜好性 / 脳機能 / fMRI / fNIRS / 食嗜好性 / 嚥下機能 / 嗅覚嗜好性
Outline of Research at the Start

超高齢社会において嚥下機能低下による摂食障害、誤嚥性肺炎の増加は大きな医療問題の一つである。申請者はこれまで、嗜好性を考慮した練習食により嚥下機能が改善した一例を経験した。本研究課題は、この経験をもとに、嗜好性を考慮した嗅覚刺激による脳機能及び身体機能の賦活効果を検証するものである。前期高齢者を含む健常ボランティアに対し、嗅覚嗜好試験、fNIRS検査などを行い嗅覚刺激による脳機能、ホルモン動態、嚥下機能の変化などを検証する。この研究成果を基に、様々な基礎疾患を有する軽度嚥下障害被検者に対する嗜好性嗅覚刺激の効果を検証する予定である。

Outline of Final Research Achievements

In order to study the relationship between food preference and brain function, we conducted experiments on fMRI and fNIRS for healthy volunteers. The sensitivity of the smell is more significant in women, and the function decreases in both sexes in age dependence. FMRI experiments show that the sex difference and age-dependent functional changes are particularly involved in the functional connectivity of the frontal medial cortex and angular gyrus. In addition, a study using fNIRS suggested that there may be differences in frontal lobe function at the time of eating depending on the living environment (whether it is with the family or alone) and the preference of the usual food (whether they like the salty taste or the mild taste). In the future, we plan to expand the number of subjects to continue the fNIRS experiment.

Academic Significance and Societal Importance of the Research Achievements

これまで、生活習慣病の治療における栄養療法において、食の嗜好性は考慮されていない。特にストレスホルモンの変化を考慮したとき、嗜好性による脳機能の差違が起こることは予想できる。しかしながら、それによる全身影響までは研究されつくしているとは言えない。本研究成果の発展により、食の嗜好性と脳機能を関連を考慮した栄養指導法の開発が期待でき、それによる栄養療法実施時のQOLの向上が期待できる。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (9 results)

All 2022 2021 2020

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (4 results)

  • [Journal Article] Frontal medial cortex and angular gyrus functional connectivity is related to sex and age differences in odor sensitivity.2022

    • Author(s)
      Takatsuru Y, Motegi S, Nishikata T, Sato H, Yonemochi K.
    • Journal Title

      J Neuroimaging.

      Volume: - Issue: 4 Pages: 611-616

    • DOI

      10.1111/jon.12994

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adult‐onset hypothyroidism causes mechanical hypersensitivity due to peripheral nerve hyperexcitability based on voltage‐gated potassium channel downregulation in male mice2021

    • Author(s)
      Suda Machiko、Takatsuru Yusuke、Amano Izuki、Haraguchi Shogo、Koibuchi Noriyuki
    • Journal Title

      Journal of Neuroscience Research

      Volume: 100 Issue: 2 Pages: 506-521

    • DOI

      10.1002/jnr.25001

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Absence of thyroid hormone induced delayed dendritic arborization in mouse primary hippocampal neurons through insufficient expression of brain-derived neurotrophic factor.2021

    • Author(s)
      Hiroyuki Yajima, Izuki Amano, Sumiyasu Ishii, Tetsushi Sadakata, Wataru Miyazaki, Yusuke Takatsuru, Noriyuki Koibuchi.
    • Journal Title

      Frontiers in Endocrinology

      Volume: 12 Pages: 1-13

    • DOI

      10.3389/fendo.2021.629100

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral Supportive Nutrition Induces Hypocupremia, Hypercholesterolemia and Potassium Increasing2020

    • Author(s)
      Takatsuru Yusuke、Seki Akemi、Shimizu-Ohmiya Hiro、Takahashi Hatuyo、Hattori Noriaki
    • Journal Title

      Aging Medicine and Healthcare

      Volume: 11 Issue: 3 Pages: 102-105

    • DOI

      10.33879/amh.113.2020.01004

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurotoxic effects of lactational exposure to perfluorooctane sulfonate on learning and memory in adult male mouse2020

    • Author(s)
      Mshaty Abdallah、Haijima Asahi、Takatsuru Yusuke、Ninomiya Ayane、Yajima Hiroyuki、Kokubo Michifumi、Khairinisa Miski Aghnia、Miyazaki Wataru、Amano Izuki、Koibuchi Noriyuki
    • Journal Title

      Food and Chemical Toxicology

      Volume: 145 Pages: 111710-111710

    • DOI

      10.1016/j.fct.2020.111710

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Functional connectivity between frontal medial cortex and angular gyrus contributes gender and age difference on odor sensitivity.2022

    • Author(s)
      Yusuke Takatsuru Shunichi Motegi Tatsuya Nishikata Keita Yonemochi
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Visualization of Protocadherin neuronal self-recognition code2021

    • Author(s)
      Ryosuke Kaneko, Manabu Abe, Yusuke Takatsuru, Yukiko U. Inoue, Masahiko Watanabe, Kenji Sakimura, Yuchio Yanagawa, Takeshi Yagi
    • Organizer
      第44回 日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] せん妄症状により救急受け入れを行った高齢者症例の傾向2020

    • Author(s)
      高鶴裕介; 服部徳昭
    • Organizer
      第35回日本老年精神医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 周産期ストレスが及ぼす“超”長期影響2020

    • Author(s)
      高鶴裕介
    • Organizer
      第36回日本ストレス学会学術総会
    • Related Report
      2020 Research-status Report

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Published: 2020-09-29   Modified: 2023-01-30  

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