| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Research Abstract |
This study suggests that, in consideration of the neurotoxic effects of methamphetamine(METH) due to oxidative stress, pharmacological intervention on NO synthase may help reduce the monoamine-depleting and apoptosis-inducing effects of methamphetamine and that pretreatment with low-dose METH may be protective against METH neurotoxicity in the midbrain, leading to the suppression of oxidative stress and apoptotic mechanisms, in part via ER stress-related pathways. In the point of view of forensic pathology, an animal model of escalation drug intake and pretraetment of low-dose METH prior to neurotoxic-dose admistration could be useful to investigate the mechanisms involved in neurotoxicity of human METH abusers.
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