| Project/Area Number |
21390380
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Junji 九州大学, 大学病院, 助教 (90529801)
TOMA Hroki 九州大学, 大学病院, 講師 (80437780)
SATO Norihro 九州大学, 大学院・医学研究院, 共同研究員 (20423527)
OHOHDA Denoki 九州大学, 大学院・医学研究院, 講師 (20452708)
冨永 洋平 九州大学, 大学院・医学研究院, 特任講師 (90304823)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 膵臓外科学 / 膵癌 / mRNA/microRNA / IPMN / mRNA / microRNA |
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| Research Abstract |
We showed that LMO2 was more frequently detected in high-grade PanIN lesions and the LMO2 messenger RNA levels were significantly higher in invasive ductal carcinoma cells. Expression of claudin-4 anSiooA4A4 mRNA is diagnostic and poor prognostic markers in PDCAMircoRNA-2l21, microRNA-li-sp5pmicroRNA-2os0MircoRNA-2l21 expression were new poor prognostic markers of PDCA. High expression omicroRNA-li-sp5pmicroRNA-2os03 modulates biological functions of pancreatic cancer cells including their proliferation, invasion and chemoresistanceMicroRNA-2ooc0c was an independent better prognostic maker in PDCA. AnmicroRNA-2l21 anmicroRNA-lss55 expression analyses in preoperative juice samples of PDCA. Expression of Reg-4 and claudin-4 were promising makers for prediction of the intestinal type in IPMN. The patients with high expression ohENT-l-1 and dCK mRNA and low expression oRRMlM1 and RRM2 and the patients with low EGFR mRNA expression were predicted for better outcome in pancreatic cancer after gemcitabine-based adjuvant chemotherapy. And high expression omicroRNA-l42-sp5p anmicroRNA-2o404 were also predictive markers for gemcitabine response after surgical resection of pancreatic cancer.
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