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Drug development using accelerated aging model

Research Project

Project/Area Number 21590289
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionJichi Medical University

Principal Investigator

KOSHIMIZU Taka-aki  自治医科大学, 医学部, 准教授 (20392491)

Co-Investigator(Renkei-kenkyūsha) TSUCHIYA Hiroyoshi  自治医科大学, 医学部, 助教 (80508755)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsバゾプレッシン / リポフスチン / 副腎皮質 / ノックアウトマウス / 受容体 / ステロイドホルモン
Research Abstract

Vasopressin is known to promote cellular growth and protein synthesis in adrenocortical and other cell types. We examined the role of V1a receptor in steroid secretion and cellular aging in adrenal cortex. In adrenocortical cell line, vasopressin promoted glucocorticoid secretion when applied alone or together with adrenocortical hormone. This study also found that V1a knockout mouse is an excellent model for studying aging in adrenocortical cells.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2012 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (3 results) Book (1 results) Remarks (2 results)

  • [Journal Article] The roles of V1a vasopressin receptors in blood pressure homeostasis : a review of studies on V1a receptor knockout mice2012

    • Author(s)
      Fujiwara Y, Tanoue A, Tsujimoto G, and Koshimizu TA.
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Pages: 30-34

    • NAID

      10030342354

    • Related Report
      2011 Final Research Report
  • [Journal Article] Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human2012

    • Author(s)
      Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Korner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Levy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, and Froguel P.
    • Journal Title

      Nature

      Volume: 483 Pages: 350-354

    • NAID

      120003874259

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] The roles of V1a vasopressin receptors in blood pressure homeostasis : a review of studies on V1a receptor knockout mice2012

    • Author(s)
      Fujiwara Y, et.al.
    • Journal Title

      Clinical and experimental nephrology

      Volume: 16 Issue: 1 Pages: 30-34

    • DOI

      10.1007/s10157-011-0497-y

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic ritodrine treatment induces refractoriness of glucose-lowering beta2 adrenoceptor signal in female mice2012

    • Author(s)
      Tsuchiya H., et.al.
    • Journal Title

      Regulatory toxicology and pharmacology

      Volume: 62 Issue: 3 Pages: 561-567

    • DOI

      10.1016/j.yrtph.2011.11.011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment.2010

    • Author(s)
      Koshimizu T, et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 392(4) Pages: 603-607

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin stimulates expression of a noncoding RNA tumor marker in a human neuroblastoma cell line.2010

    • Author(s)
      Koshimizu T, et al.
    • Journal Title

      Life Sciences

      Volume: 86 Pages: 455-460

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vasopressin regulation of blood pressure and volume : findings from V1a receptor-deficient mice2009

    • Author(s)
      Aoyagi, T., Koshimizu, T., et.al.
    • Journal Title

      Kidney International 76

      Pages: 1035-1039

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 広域性神経ペプチドアンクゴニストによるバプレッシン受容体シグナルの制御機構2011

    • Author(s)
      輿水崇鏡
    • Organizer
      日本神経内分泌学会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment2010

    • Author(s)
      Koshimizu, et al.
    • Organizer
      16th World Congress of Basic and Clinical Pharmacology
    • Place of Presentation
      ベルギー コペンハーゲン
    • Year and Date
      2010-07-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Critical roles of V1a and V1b vasopressin receptors in systemic blood pressure Homeostasis : studies from gene knockout mice2009

    • Author(s)
      Koshimizu T, et.al.
    • Organizer
      Mechanisms of Vasodilatation Conference
    • Place of Presentation
      ホテル松島大観荘(宮城県)
    • Year and Date
      2009-06-02
    • Related Report
      2009 Annual Research Report
  • [Book] 標準医療薬学 薬理学2009

    • Author(s)
      輿水崇鏡
    • Total Pages
      11
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.jichi.ac.jp/molpharm/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.jichi.ac.jp/molpharm/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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