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Prevention of HCC recurrence by Radiofrequency ablation with Glypican-3 epitope peptide injection to tumor site

Research Project

Project/Area Number 21591756
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKumamoto University

Principal Investigator

KOMORI Hiroyuki  熊本大学, 医学部附属病院, 非常勤診療医師 (50444881)

Co-Investigator(Kenkyū-buntansha) BEPPU Toru  熊本大学, 医学部附属病院, 准教授 (70301372)
HORINO Kei  熊本大学, 医学部附属病院, 非常勤診療医師 (60452900)
BABA Hideo  熊本大学, 大学院・生命科学研究部, 教授 (20240905)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsCTL / GPC3 / HCC / RFA / ペプチドワクチン / GPC3ペプチド / 肝細胞癌 / 腫瘍抗原特異的CTL
Research Abstract

Injection of Glypican-3(GPC3) epitope peptide to tumor site of Hepatocellular carcinoma(HCC) in Radiofrequency ablation(RFA) reasonable to be adjuvant immunotherapy preventing recurrence of HCC after treatment with stimulating dendritic cells.
We previously reported that DC vaccine stimulated by GPC3 peptide could suppress the GPC3+tumor growth. And also GPC3 specific CTLs, isolated from HCC patients, could reduce growth of GPC3+human HCC tumor cell line implanted into NOD/SCID mouse.
Nakatura T et al studied prospectively HCC patients treated with locoregional therapies, including radiofrequency ablation(RFA) and surgical resection. Circulating GPC3-specific CTLs were increased in 5 of 9 patients after RFA, but in only 1 of 9 patients after surgical resection.
The number of increased GPC3-specific CTLs after RFA was significantly larger than that after surgical resection. The safety of GPC3 peptide vaccination was checked in phase 1 study by Nakatsura and collaborators at National Cancer Center East. We will try to check the more effective interval time from RFA to injection epitope peptide into tumor site, and more effective doze of that. In clinical study, we want to make sure this strategy may be a novel adjuvant immunotherapy that can potentially help to prevent the appearance, advance and/or recurrence of HCC.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report

Research Products

(7 results)

All 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] 広範囲血液・尿化学検査免疫学的検査[第7版]その数値をどう読むか2010

    • Author(s)
      小森宏之、西村泰治
    • Journal Title

      日本臨床68 :増刊号7広範囲血液・尿化学検査免疫学的検査

      Volume: 4巻 Pages: 833-836

    • Related Report
      2011 Final Research Report
  • [Journal Article] 【広範囲血液・尿化学検査免疫学的検査[第7版] その数値をどう読むか】腫瘍マーカーGPC3(glypican-3)2010

    • Author(s)
      小森宏之、西村泰治
    • Journal Title

      日本臨床 68:増刊号7 広範囲血液・尿化学検査 免疫学的検査

      Volume: 4 Pages: 833-836

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Occurrence of hepatocellular carcinoma after a hepatic resection of ahepatoblastoma in an adult patient with hepatitis C virus.2009

    • Author(s)
      Masuda T
    • Journal Title

      Hepatolo Res

      Volume: 39巻 Pages: 525-530

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 肝癌に対する免疫療法に有用な癌抗原特異的CTL誘導ペプチドの同定と臨床応用への試み2009

    • Author(s)
      小森宏之
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      神奈川 パシフィコ横浜
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝切除後における胆汁外瘻化が肝再生を阻害する2009

    • Author(s)
      太田尾龍
    • Organizer
      第109回日本外科学会
    • Place of Presentation
      福岡県福岡国際会議場
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 経皮経肝門脈塞栓術は肝細胞癌の右肝切除における無再発生存率を向上させる2009

    • Author(s)
      崔林承
    • Organizer
      第109回日本外科学会
    • Place of Presentation
      福岡県福岡国際会議場
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝癌におけるmyofibroblastの関与2009

    • Author(s)
      Hasita
    • Organizer
      第109回日本外科学会
    • Place of Presentation
      福岡県福岡国際会議場
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report

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Published: 2009-03-31   Modified: 2016-04-21  

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