Originally Synthesized Oxy-Redox Sensitive Contrast Substances for in vivo Mapping of Tissue Redox and Oxidant Status in Cancer Using High Field MRI
| Project/Area Number |
21611011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical Physics/Radiological Technology
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
ZHELEV Zhivko 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (60511532)
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| Co-Investigator(Renkei-kenkyūsha) |
AOKI Ichio 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10319519)
BAKALOVA Rumiana 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (30469936)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | MRI / Cancer / Nitroxyl / ニトロキシルラジカル / 酸化還元 / ESR / マウス / 酸化還元状態 / 大腸がん / 高磁場MRI / フリーラジカル / 電子スピン共鳴 / nitroxide / neuroblastoma |
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| Research Abstract |
I investigated the redox potential, hydrophobicity and T_1 relaxivity of 15 redox sensitive nitroxide probes, using voltametry, EPR spectroscopy and T_1 weighted MRI. The probes were classified in three groups, depending on their hydrophobicity-hydrophilic, slightly hydrophobic and strongly hydrophobic. In each group the probes were classified in two subgroups, depending on its resistance to reduction-rapidly reducing and slowly reducing. Four probes were selected for application in imaging of tissue redox activity in experimental animals using MRI. I established that there is difference in tissue redox activity between early and moderate/terminal stage of cancer development, as well as between tumor core and tumor periphery.
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Report
(4 results)
Research Products
(27 results)
