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The analysis of cell death mechanism that depended on newly isolated nucleolar GTP binding protein.

Research Project

Project/Area Number 21658020
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Applied entomology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

TSUNEIZUMI Kazuhide  独立行政法人理化学研究所, 松本分子昆虫学研究室, 専任研究員 (40280953)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,370,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2009: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsnucleostemin / apoptosis / cell death / ribosomal biogenesis / GTP binding protein / Drosophila / nucleolus
Research Abstract

In this study, I made clear that an intracellular signal-transducing pathway of dNS1 to cell death was independent from p53 and there was big difference in intracellular mechanism between vertebrate and Drosophila. I succeeded in the isolation of interactive factors to dNS1 and the screening for small molecular compounds that directly modulate the activity of dNS1.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (15 results)

All 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (6 results)

  • [Journal Article] Establishment of Sf9 transformants constitutively expressing PBAN receptor variants : application to functional evaluation2012

    • Author(s)
      J. M. Lee, J. J. Hull, T. Kawai, K. Tsuneizumi, M. Kurihara, M. Tanokura, K. Nagata, H. Nagasawa and S. Matsumoto
    • Journal Title

      Frontiers in Experimental Endocrinology

      Volume: (In press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drosophila GTPase Nucleostemin 2 changes cellular distribution during larval development and GTP-binding motif is essential for the nucleoplasmic localization2011

    • Author(s)
      E. Matsuo, T. Nagamine, S. Matsumoto and K. Tsuneizumi
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 75(8) Pages: 1511-1515

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hormone signaling linked to silkmoth sex pheromone biosynthesis involves Ca^<2+>/calmodulin-dependent protein kinase II(CaMKII)-mediated phosphorylation of the insect PAT family protein Bombyx mori lipid storage droplet protein-1(BmLSD1)2011

    • Author(s)
      A. Ohnishi, J. J. Hull, M. Kaji, K. Hashimoto, J. M. Lee, K. Tsuneizumi, T. Suzuki, N. Dohmae, and S. Matsumoto
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286(27) Pages: 24101-24112

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Robustness of the Dpp morphogen activity gradient depends on negative feedback regulation by the inhibitory Smad, Dad2011

    • Author(s)
      Y. Ogiso, K. Tsuneizumi, N. Masuda, M. Sato and T. Tabata
    • Journal Title

      Development Growth and Differentiation

      Volume: 53(5) Pages: 668-678

    • NAID

      10029006163

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drosophila GTPase Nucleostemin 2 Changes Cellular Distribution during Larval Development and the GTP-Binding Motif Is Essential to Nucleoplasmic Localization2011

    • Author(s)
      E.Matsuo, T.Nagamine, S.Matsumoto, K.Tsuneizumi
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 75 Issue: 8 Pages: 1511-1515

    • DOI

      10.1271/bbb.110212

    • NAID

      10029591473

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hormone signaling linked to silkmoth sex pheromone biosynthesis involves Ca^<2+>/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of the insect PAT family protein Bomhyx mori lipid storage droplet protein-1 (BmLSD1)2011

    • Author(s)
      A.Ohnishi, J.J.Hull, M.Kaji, K.Hashimoto, J.M.Lee, K.Tsuneizumi, T.Suzuki, N.Dohmae, S.Matsumoto
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286 Issue: 27 Pages: 24101-24112

    • DOI

      10.1074/jbc.m111.250555

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drosophila nucleostemin 2 proved essential for early eye development and cell survival2010

    • Author(s)
      E. Matsuo, S. Kanno, S. Matsumoto and K. Tsuneizumi
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 74(10) Pages: 2120-2123

    • NAID

      10027560856

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drosophila Nucleostemin 2 Proved Essential for Early Eye Development and Cell Survival.2010

    • Author(s)
      松尾恵倫子
    • Journal Title

      Biosci.Biotechnol.Biochem.

      Volume: 74 Pages: 2120-2123

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robustness of the Dpp morphogen activity gradient depends on negative feedback regulation by the inhibitory Smad, Dad.

    • Author(s)
      小木曽由梨
    • Journal Title

      Development Growth and Differentiation

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ショウジョウバエ新規遺伝子Drosophila nucleostemin 2の機能解析2011

    • Author(s)
      松尾恵倫子、永峰俊弘、松本正吾、常泉和秀
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都(東山区)
    • Year and Date
      2011-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] ショウジョウバエ新規遺伝子Drosophila nucleostemin 2の機能解析2011

    • Author(s)
      松尾恵倫子
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都府京都市
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional analysis of Drosophila nucleolar GTP binding protein 1(dngbp1) in response to stress2010

    • Author(s)
      K. Tsuneizumi and S. Matsumoto
    • Organizer
      RIKEN Symposium on 2010 RIKEN Chemical Biology International Symposium
    • Place of Presentation
      Saitama(Wako)
    • Year and Date
      2010-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] ショウジョウバエ新規遺伝子Drosophila nucleolar GTP binding protein 2の機能解析2010

    • Author(s)
      松尾恵倫子、常泉和秀、松本正吾
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京(文京区)
    • Year and Date
      2010-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] ショウジョウバエ新規遺伝子 Drosophila nucleolar GTP binding protein 2の機能解析2010

    • Author(s)
      松尾恵倫子
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京都目黒区
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional analysis of Drosophila nucleolar GTP binding protein 1 (dngbp1) in response to stress.2010

    • Author(s)
      常泉和秀
    • Organizer
      2010 RIKEN Chemical Biology International Symposium
    • Place of Presentation
      埼玉県和光市
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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