The analysis of cell death mechanism that depended on newly isolated nucleolar GTP binding protein.
Project/Area Number |
21658020
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Single-year Grants |
Research Field |
Applied entomology
|
Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
TSUNEIZUMI Kazuhide 独立行政法人理化学研究所, 松本分子昆虫学研究室, 専任研究員 (40280953)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,370,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2009: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
Keywords | nucleostemin / apoptosis / cell death / ribosomal biogenesis / GTP binding protein / Drosophila / nucleolus |
Research Abstract |
In this study, I made clear that an intracellular signal-transducing pathway of dNS1 to cell death was independent from p53 and there was big difference in intracellular mechanism between vertebrate and Drosophila. I succeeded in the isolation of interactive factors to dNS1 and the screening for small molecular compounds that directly modulate the activity of dNS1.
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Report
(4 results)
Research Products
(15 results)