The role of Janus tyrosine kinase(JAK) signal transducer and activator of transcription(STAT) and suppressor of cytokine signaling (SOCS) pathway in the renal interstitial fibrosis after unilateral ureteral obstruction
Project/Area Number |
21790826
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Kidney internal medicine
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Research Institution | Kurume University |
Principal Investigator |
KOIKE Kiyomi 久留米大学, 医学部, 助教 (80389270)
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Project Period (FY) |
2009 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 腎線維化 / JAK/STAT/SOCS / 片側尿管結紮モデル / JAK / STAT / SOCS |
Research Abstract |
Protective role of JAK/STAT signaling against renal fibrosis in mice with unilateral ureteral obstructionJAK/STAT system is an essential intracellular signaling pathway of various cytokines and stimuli that could regulate a variety of inflammatory reactions, proliferation, and differentiation. SOCS work as a negative feedback pathway of this system. JAK/STAT/SOCS system may play an important role in renal responses. To clarify how JAK/STAT/SOCS system was involved in renal fibrosis, unilateral ureteral obstruction (UUO) was induced in BALB/c or SOCS3 heterozygous knockout (SOCS3+/-) mice in the presence or absence of JAK inhibitor-incorporated nanoparticle (pyridine6-PGLA). Our present study suggests that JAK/STAT3 signaling may play an important role in repair process of renal fibrosis in UUO partly via activation of MMP-2.
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Report
(5 results)
Research Products
(9 results)
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[Journal Article] Experimental diabetic nephropathy is accelerated in matrix metalloproteinase-2 knockout mice.2013
Author(s)
Takamiya Y, Fukami K, Yamagishi S, Kaida Y, Nakayama Y, Obara N, Iwatani R, Ando R, Koike K, Matsui T, Nishino Y, Ueda S, Cooper ME, Okuda S.
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Journal Title
Nephrol Dial Transplant.
Volume: 28(1)
Pages: 55-62
Related Report
Peer Reviewed
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[Journal Article] A new vasculitis activity score for predicting death in myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis patients.2012
Author(s)
Koike K, Fukami K, Yonemoto K, Iwatani R, Obata R, Ueda K, Toyonaga M, Ueda S, Ohara A, Takeda K, Yamagishi S, Okuda S.
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Journal Title
Am J Nephrol.
Volume: 35(1)
Pages: 1-6
Related Report
Peer Reviewed
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[Journal Article] Interstitial Foxp3-positive T cells may predict renal survival in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.2010
Author(s)
Yoshimura J, Fukami K, Koike K, Nagano M, Matsumoto T, Iwatani R, Kusumoto T, Hazama T, Ueda S, Adachi H, Hirai Y, Takasu K, Ohshima K, Yamagishi S, Okuda S.
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Journal Title
Clin Exp Pharmacol Physiol.
Volume: 37(9)
Pages: 879-83
Related Report
Peer Reviewed
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