Investigation the mechanism and the role of RNA activation by micro RNA in pancreatic cancer

• Project/Area Number: 22390258
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: NAGAI Eishi 九州大学, 医学研究院, 准教授 (30264021)
• Co-Investigator(Kenkyū-buntansha): TOMA Hiroki 九州大学, 医学研究院, 共同研究員 (80437780) ; EGAMI Takuya 九州大学, 医学研究院, 共同研究員 (40507787) ; MIZUMOTO Kazuhiro 九州大学, 大学病院, 准教授 (90253418) ; UEDA Junji 九州大学, 大学病院, 助教 (90529801) ; TOMINAGA Yohei 九州大学, 医学研究院, 共同研究員 (90304823) ; OHUCHIDA Kenoki 九州大学, 先端イノベーションセンター, 講師 (20452708) ; TANAKA Masao 九州大学, 医学研究院, 教授 (30163570)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 膵癌 / microRNA / IPMN

Research Abstract

We investigated miRNA expression in pancreatic cancer. We found miR-10b expression is overexpressed and miR-X(now submitting) expression is inhibited in pancreatic cancer. We also found miR-10b is related with pancreatic cancer invasiveness and its expression is related with poor prognosis.

Research Products

• [Journal Article] Feasibility and safety of intracorporeal esophagojejunostomy after laparoscopic total gastrectomy: Inverted T-shaped anastomosis using linear staplers (2013)
  • Author(s): Nagai E, Ohuchida K, Nakata K, Toma H, Tanaka M
  • Journal Title: Surgery Volume: 153(5) Pages: 732-8
• [Journal Article] MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness partially via suppression of the HOXA gene (2012)
  • Author(s): Ohuchida K, Mizumoto K, Nagai E, Tanaka M et al
  • Journal Title: Ann Surg Oncol Volume: 19(7) Pages: 2394-402
• [Journal Article] Feasibility of laparoscopic gastrectomy for advanced gastric cancer with positive peritoneal cytology (2012)
  • Author(s): Yamanaka N, Nagai E, Ohuchida K, Ueda J, Toma H, Tanaka M
  • Journal Title: Surg Today
  • NAID: 10031189764
• [Journal Article] The risk of lymph node metastasis in mucosal gastric carcinoma: especially for a mixture of differentiated and undifferentiated adenocarcinoma (2012)
  • Author(s): Nakata K, Nagai E, Ohuchida K, Ohtsuka T, Toma H, Tanaka M
  • Journal Title: Hepatogastroenterology Volume: 59(118) Pages: 1855-8
• [Journal Article] MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness and is correlated with a poor prognosis (2011)
  • Author(s): Nakata K, Ohuchida K, Mizumoto K, Nagai E, Tanaka M
  • Journal Title: Surgery Volume: 150 Pages: 916-22
• [Journal Article] Invasive carcinoma derived from intestinal type intraductal papillary mucinous neoplasm is associated with minimal invasion colloid carcinoma, and less invasisve behabiors, leading to better prognosis (2011)
  • Author(s): Nakata K, Ohuchida K, Nagai E, Mizumoto K
  • Journal Title: Pancreas Volume: 40 Pages: 581-7
• [Journal Article] Single-incision laparoscopy -assisted surgery for bowel obstruction: report of three cases (2011)
  • Author(s): Ohtsuka T, Nagai E, Toma H, Ohuchida K, Tanaka M
  • Journal Title: Surg Today Volume: 41(11) Pages: 1519-23
  • NAID: 10030229390
• [Journal Article] Senescence in intraductal papillary mucinous neoplasm of the pancreas (2011)
  • Author(s): Miyasaka Y, Nagai E, Ohuchida K, Mizumoto K, Tsuneyoshi M, Tanaka M
  • Journal Title: Hum Pathol Volume: 42(12) Pages: 2010-7
• [Journal Article] Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior , leading to a better prognosis (2011)
  • Author(s): Nakata K, Ohuchida K, Aishima S, Sadakari Y, Kayashima T, Miyasaka Y, Nagai E, Mizumoto K, Tanaka M
  • Journal Title: Pancreas Volume: 40(4) Pages: 581-7
• [Journal Article] Inhibition of p600 expression suppresses both invasiveness and anoikis resistance of gastric cancer (2011)
  • Author(s): Sakai H, Ohuchida K, Mizumoto K, Cui L, Nakata K, Toma H, Nagai E, Tanaka M
  • Journal Title: Ann Surg Oncol Volume: 18(7) Pages: 2057-65
• [Journal Article] MicroRNA expression as a predictive marker for gemcitabine response after surgical resection of pancreatic cancer (2011)
  • Author(s): Ohuchida K, Mizumoto K, Kayashima T, Ueda J, Nagai E, Tanaka M
  • Journal Title: Ann Surg Oncol Volume: 18(8) Pages: 2381-7
• [Journal Article] MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis (2011)
  • Author(s): Nakata K, et al
  • Journal Title: Surgery Volume: 150 Pages: 916-922
  • Peer Reviewed
• [Journal Article] Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis (2011)
  • Author(s): Nakata K, et al
  • Journal Title: Pancreas Volume: 40 Pages: 581-587
  • Peer Reviewed
• [Journal Article] Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation (2010)
  • Author(s): Hayashi A, Nakata K, Nagai E, Oda Y, Tanaka M
  • Journal Title: Hum Pathol Volume: 41(11) Pages: 1507-15
  • NAID: 120005227180
• [Journal Article] Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells (2010)
  • Author(s): Onimaru M, Ohuchida K, Egami T,Mizumoto K, Nagai E, Toma H, Tanaka M
  • Journal Title: Cancer Gene Ther Volume: 17(8) Pages: 541-9
• [Journal Article] Decreased expression of focal adhesion kinase is associated with a poor prognosis in extrahepatic bile duct carcinoma (2010)
  • Author(s): Hayashi A, Nagai E, Tanaka M
  • Journal Title: Hum Pathol Volume: 41(6) Pages: 859-66
• [Journal Article] Combination with low-dose gemcitabine andhTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer (2010)
  • Author(s): Onimaru M, Ohuchida K, Nagai E,Mizumoto K, Egami T, Tanaka M
  • Journal Title: Cancer Lett Volume: 294(2) Pages: 178-86
• [Journal Article] S100P is a novel marker to identify intraductal papillary mucinous neoplasms (2010)
  • Author(s): Nakata K, Nagai E, Ohuchida K, Mizumoto K, Tanaka M
  • Journal Title: Hum Pathol Volume: 41(6) Pages: 824-31
• [Presentation] MicroRNA-373 is downregulated in pancreatic cancer and repressed its invasiveness via induction of mesenchymal-episerial transition (2010)
  • Author(s): Nakata K, Ohuchida K, Mizumoto K, Nagai E and Tanaka M
  • Organizer: Joint meeting of the international association of pancreatology and Japan pancreatic society
  • Place of Presentation: Fukuoka, Japan
• [Presentation] MicroRNA-10b is a useful prognostic marker in pancreatic cancer and promotes its invasiveness (2010)
  • Author(s): Nakata K, Ohuchida K, Mizumoto K, Nagai E and Tanaka M
  • Organizer: Joint meeting of the international association of pancreatology and Japan pancreatic society
  • Place of Presentation: Fukuoka, Japan