Project/Area Number |
22590098
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Drug development chemistry
|
Research Institution | University of Toyama |
Principal Investigator |
TEZUKA Yasuhiro 富山大学, 和漢医薬学総合研究所, 准教授 (70236975)
|
Co-Investigator(Kenkyū-buntansha) |
TOYOOKA Naoki 富山大学, 大学院・理工学研究部(工学), 教授 (10217565)
SURESH Awale 富山大学, 先端ライフサイエンス拠点, 特命助教 (00377243)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 医薬品化学 / 癌 / 栄養飢餓耐性 / 和漢薬 / 膵臓がん / 抗がん剤 / アルクチゲニン / PANC-1 |
Research Abstract |
From Arctium lappa, Wikstroemia indica, and Trachelospermum asiaticum, we obtained the (-)-arctigenin-relating compounds and measured their preferential cytotoxicity under nutrient-deprived conditions. Based on the preferential cytotoxicity, we have synthesized the (-)-arctigenin derivatives and clarified that the triethoxy derivative shows the important in vitro and in vivo activity identical with those of (-)-arctigenin.
|