| Project/Area Number |
22590098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
|
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| Research Institution | University of Toyama |
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Principal Investigator |
TEZUKA Yasuhiro 富山大学, 和漢医薬学総合研究所, 准教授 (70236975)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOYOOKA Naoki 富山大学, 大学院・理工学研究部(工学), 教授 (10217565)
SURESH Awale 富山大学, 先端ライフサイエンス拠点, 特命助教 (00377243)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 医薬品化学 / 癌 / 栄養飢餓耐性 / 和漢薬 / 膵臓がん / 抗がん剤 / アルクチゲニン / PANC-1 |
|---|
| Research Abstract |
From Arctium lappa, Wikstroemia indica, and Trachelospermum asiaticum, we obtained the （-)-arctigenin-relating compounds and measured their preferential cytotoxicity under nutrient-deprived conditions. Based on the preferential cytotoxicity, we have synthesized the （-)-arctigenin derivatives and clarified that the triethoxy derivative shows the important in vitro and in vivo activity identical with those of （-)-arctigenin.
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