Development of a new pancreatic cancer curative medicine from arctigenin, an ingredient of Wakan-yaku "Burdock Fruit (Seeds of Arctium lappa)"
Project/Area Number |
22590098
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Drug development chemistry
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Research Institution | University of Toyama |
Principal Investigator |
TEZUKA Yasuhiro 富山大学, 和漢医薬学総合研究所, 准教授 (70236975)
|
Co-Investigator(Kenkyū-buntansha) |
TOYOOKA Naoki 富山大学, 大学院・理工学研究部(工学), 教授 (10217565)
SURESH Awale 富山大学, 先端ライフサイエンス拠点, 特命助教 (00377243)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 医薬品化学 / 癌 / 栄養飢餓耐性 / 和漢薬 / 膵臓がん / 抗がん剤 / アルクチゲニン / PANC-1 |
Research Abstract |
From Arctium lappa, Wikstroemia indica, and Trachelospermum asiaticum, we obtained the (-)-arctigenin-relating compounds and measured their preferential cytotoxicity under nutrient-deprived conditions. Based on the preferential cytotoxicity, we have synthesized the (-)-arctigenin derivatives and clarified that the triethoxy derivative shows the important in vitro and in vivo activity identical with those of (-)-arctigenin.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy2013
Author(s)
Kudou N., Taniguchi A., Sugimoto A., Matsuya Y., Kawasaki M., Toyooka N., Miyoshi C., Awale S., Dibwe D.F., Esumi H., Kadota S., and Tezuka Y
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Journal Title
Eur. J. Med. Chem
Volume: 60
Pages: 76-88
DOI
Related Report
Peer Reviewed
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[Presentation] 栄養飢餓耐性解除に基づく新規膵臓がん治療薬の開発研究2012
Author(s)
谷口 瑛,工藤直紀,松谷裕二,杉本健士,友廣岳則,畑中保丸,川崎正志,Suresh Awale,李 峰,手塚康弘,門田重利,三好千香,江角浩安,豊岡尚樹
Organizer
第42回複素環化学討論会
Place of Presentation
京都
Related Report
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[Presentation] 栄養飢餓耐性解除に基づく新規膵臓がん治療薬の開発研究2011
Author(s)
谷口 瑛,工藤直紀,松谷裕二,杉本健士,川崎正志,Suresh Awale,手塚康弘,門田重利,三好千香,江角浩安,豊岡尚樹
Organizer
平成23年度有機合成化学北陸セミナー
Place of Presentation
福井県坂井市
Related Report