Possible mechanisms of galectin-9-induced immunoregulatory macrophages

• Project/Area Number: 22590360
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kagawa University
• Principal Investigator: HIRASHIMA Mitsuomi 香川大学, 医学部, 客員研究員 (70109700)
• Co-Investigator(Kenkyū-buntansha): OOMIZU Souichi 香川大学, 医学部, 助教 (00444729) ; NIKI Toshiro 香川大学, 医学部, 助教 (40558508)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ガレクチン 9 / 免疫学 / 癌 / 炎症 / マクロファージ / ガレクチン9

Research Abstract

We described that galectin-9 regulates functions of not only immunocompetent cells but also various cells by collaboration with world-wide investigators. From our works, it is suggested that galectins including galectin-9 play a role as an important factor to overcome stress, because galectins are conserved longtime from fungi and sea sponge to human.

Research Products

• [Journal Article] HCV-infected hepatocytes drive CD4+ CD25+ Foxp3+ regulatory T-cell development through the Tim-3/Gal-9 pathway. (2013)
  • Author(s): Ji XJ, Ma CJ, Wang JM, Wu XY, Niki T,Hirashima M, Moorman JP, Yao ZQ
  • Journal Title: Eur J Immunol. Volume: 43 Pages: 458-67
• [Journal Article] A possible role of galectin-9 in the pulmonary fibrosis of patients with interstitial pneumonia (2013)
  • Author(s): Matsumoto N, Katoh S, Yanagi S, Arimura Y, Tokojima M, Ueno M, Hirashima M, Nakazato M.
  • Journal Title: Lung Volume: 191 Pages: 191-8
• [Journal Article] Self-association of the galectin-9 C-terminal domain via the opposite surface of the sugar-binding site (2013)
  • Author(s): Nonaka Y, Ogawa T, Oomizu S, Nakakita SI, Nishi N, Kamitori S,Hirashima M, Nakamura T.
  • Journal Title: J Biochem. Volume: 153 Pages: 463-71
  • NAID: 40019646873
• [Journal Article] Galectin-9 functionally impairs natural killer cells in humans and mice. (2013)
  • Author(s): Golden-Mason L, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen HR.
  • Journal Title: J Virol Volume: 87 Pages: 4838-45
• [Journal Article] Galectin-9 in cancer therapy (2013)
  • Author(s): Fujihara S, Mori H, Kobara H, Rafiq K, Niki T, Hirashima M, Masaki T.
  • Journal Title: Recent Pat Endocr Metab Immune Drug Discov Volume: 7 Pages: 130-7
• [Journal Article] Galectin-9 Ameliorates Clinical Severity of MRL/lpr Lupus-Prone Mice by Inducing Plasma Cell Apoptosis Independently of Tim-3. (2013)
  • Author(s): Moritoki M, Kadowaki T, Niki T, Nakano D, Soma G, Mori H, Kobara H, Masaki T, Kohno M, Hirashima M.
  • Journal Title: PLoS One Volume: 8
• [Journal Article] Galectin-9 Ameliorates Clinical Severity of MRL/lpr Lupus-Prone Mice by Inducing Plasma Cell Apoptosis Independently of Tim-3 (2013)
  • Author(s): Moritoki M
  • Journal Title: PLoS One Volume: in press
  • Peer Reviewed
• [Journal Article] Galectin-9 in cancer therapy (2013)
  • Author(s): Fujihara S
  • Journal Title: Recent Pat Endocr Metab Immune Drug Discov Volume: in press
  • Peer Reviewed
• [Journal Article] Galectin-9 functionally impairs natural killer cells in humans and mice (2013)
  • Author(s): Golden-Mason L
  • Journal Title: J Virol Volume: in press
  • Peer Reviewed
• [Journal Article] Self-association of the galectin-9 C-terminal domain via the opposite surface of the sugar-binding site (2013)
  • Author(s): Nonaka Y
  • Journal Title: J Biochem Volume: in press
  • Peer Reviewed
• [Journal Article] HCV-infected hepatocytes drive CD4+ CD25+ Foxp3+ regulatory T-cell development through the Tim-3/Gal-9 pathway (2013)
  • Author(s): Ji XJ
  • Journal Title: Eur J Immunol Volume: 43(2) Pages: 458-67
  • Peer Reviewed
• [Journal Article] The increase of plasma galectin-9 in a patient with insulin allergy: a case report. (2012)
  • Author(s): H. Chagan-Yasutan, B. Shiratori, UR. Siddiqi, H. Saitoh, Y. Ashino, T.Arikawa, M. Hirashima, T. Hattori.
  • Journal Title: Clin Mol Allergy Volume: 8
• [Journal Article] Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages. (2012)
  • Author(s): Kadowaki T, Arikawa T, Shinonaga R, Oomizu S, Inagawa H, Soma G, Niki T, Hirashima M
  • Journal Title: Clin Immunol Volume: 142 Pages: 296-307
• [Journal Article] Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner (2012)
  • Author(s): Oomizu S, Arikawa, T, Kadowaki T, Ueno M, Nishi N, Yamauchi A, Hirashima M
  • Journal Title: Clin Immunol Volume: 143 Pages: 51-58
• [Journal Article] Galectin-9 ameliorates herpes simplex-induced inflammation through apoptosis (2012)
  • Author(s): Shim JA, Park S, Lee ES, Niki T, Hirashima M, Sohn S
  • Journal Title: Immunobiology Volume: 217 Pages: 657-66
• [Journal Article] Tim-3 is an inducible human NK cell receptor that enhances interferon gamma production in response to galectin-9 (2012)
  • Author(s): MK. Gleason, TR. Lenvik, V. McCullar, M.Felices, MS. O'Brien, SA. Cooley, MR. Verneris, F. Cichocki, CJ. Holman, A.Panoskaltsis-Mortari, T. Niki, M.Hirashima, B.R. Blazar, JS. Miller
  • Journal Title: Blood Volume: 119 Pages: 3064-72
• [Journal Article] IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma (2012)
  • Author(s): ZZ. Yang, DM. Grote, SC. Ziesmer, T. Niki, M. Hirashima, AJ. Novak, TE. Wizig, SM. Ansell.
  • Journal Title: J. Clin Invest Volume: 122 Pages: 1271-82
• [Journal Article] Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection (2012)
  • Author(s): S. Elahi, T. Niki, M. Hirashima, H. Horton.
  • Journal Title: Blood Volume: 120 Pages: 682-90
• [Journal Article] The glycan-binding protein Galectin-9 has direct apoptotic activity towards melanoma cells (2012)
  • Author(s): Wiersma VR, de Bruyn M, van Ginkel RJ, Sigar E, HirashimaM, Niki T, Nishi N, Samplonius DF, Helfrich W, Bremer E.
  • Journal Title: J Invest Dermatol Volume: 132 Pages: 2302-5
• [Journal Article] Contrasting acute graft-versus-host disease effects ofTim-3/galectin-9 pathway blockade dependent upon the presence ofdonor regulatory T cells. (2012)
  • Author(s): Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VKK, Blazar BR.
  • Journal Title: Blood Volume: 120 Pages: 682-90
• [Journal Article] A novel monoclonal antibody fordetection ofgalectin-9 intissue sections: application tohuman tissues infected byoncogenic viruses. (2012)
  • Author(s): Barjon C, Niki T, Verillaud B, Opolon P, Bedossa P,Hirashima M, Blanchin S, Wassef M, Rosen HR, Jimenez AS, Wei M, Busson P
  • Journal Title: Infect Agent Cancer Volume: 7 Pages: 16-16
• [Journal Article] TNFRSF25 Agonistic Antibody andGalectin-9 Combination Therapy Controls Herpes Simplex Virus-Induced Immunoinflammatory Lesions. (2012)
  • Author(s): J Reddy PB, Schreiber TH, Rajasagi NK, Suryawanshi A, Mulik S, Veiga-Parga T, Niki T, Hirashima M, Podack ER, Rouse BT
  • Journal Title: J Virol Volume: 86 Pages: 10606-20
• [Journal Article] Tumor-infiltrating DCssuppress nucleic acid-mediated innate immune responses through interactions between thereceptor TIM-3 and thealarmin HMGB1. (2012)
  • Author(s): Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Fujioka Y, Ohba Y, Gorman JV, Colgan JD, Hirashima M, Uede T, Takaoka A, Yagita H, Jinushi M.
  • Journal Title: Nat Immunol Volume: 13 Pages: 832-42
• [Journal Article] Rapid Decrease ofPlasma Galectin-9 Levels inPatients with Acute HIVInfection after Therapy (2012)
  • Author(s): Saitoh H, Ashino Y, Chagan-Yasutan H, Niki T, Hirashima M, Hattori T.
  • Journal Title: Tohoku J Exp Med Volume: 228 Pages: 157-61
• [Journal Article] Cell surface galectin-9 expressing th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion (2012)
  • Author(s): Oomizu S, Arikawa T, Niki T, Kadowaki T, Ueno M, Nishi N, Yamauchi A, Hattori T, Masaki T, Hirashima M.
  • Journal Title: PLoS One Volume: 7
• [Journal Article] Cell surface galectin-9 expressing th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion (2012)
  • Author(s): Oomizu S
  • Journal Title: PLoS One Volume: 7(11)
  • Peer Reviewed
• [Journal Article] Rapid decrease of plasma galectin-9 levels in patients with acute HIV infection after therapy (2012)
  • Author(s): Saitoh H
  • Journal Title: Tohoku J Exp Med Volume: 228(2) Pages: 157-61
  • Peer Reviewed
• [Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. S. (2012)
  • Author(s): Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J. V. Gorman, J. D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.
  • Journal Title: Nat. Immunol. Volume: 13 Issue: 9 Pages: 832-842
  • DOI: 10.1038/ni.2376
  • Peer Reviewed
• [Journal Article] TNFRSF25 agonistic antibody and galectin-9 combination therapy controls herpes simplex virus-induced immunoinflammatory lesions (2012)
  • Author(s): Reddy PB
  • Journal Title: J Virol Volume: 86(19) Pages: 10606-20
  • Peer Reviewed
• [Journal Article] A novel monoclonal antibody for detection of galectin-9 in tissue sections: application to human tissues infected by oncogenic viruses (2012)
  • Author(s): Barjon C
  • Journal Title: Infect Agent Cancer Volume: 17;7(1) Issue: 1 Pages: 16-16
  • DOI: 10.1186/1750-9378-7-16
  • Peer Reviewed
• [Journal Article] Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells (2012)
  • Author(s): Veenstra RG
  • Journal Title: Blood. Volume: 19;120(3) Pages: 682-90
  • Peer Reviewed
• [Journal Article] Possible regulatory role of galectin-9 on Ascaris suum-induced eosinophilic lung inflammation in mice (2012)
  • Author(s): Katoh S
  • Journal Title: Int Arch Allergy Immunol Volume: 158 Suppl 1 Pages: 58-65
  • Peer Reviewed
• [Journal Article] Reconsideration of macrophage and dendritic cell classification (2012)
  • Author(s): Kadowaki T
  • Journal Title: Anticancer Res. Volume: 32(6) Pages: 2257-61
  • Peer Reviewed
• [Journal Article] The glycan-binding protein galectin-9 has direct apoptotic activity toward melanoma cells (2012)
  • Author(s): Wiersma VR
  • Journal Title: J Invest Dermatol Volume: 132(9) Pages: 2302-5
  • Peer Reviewed
• [Journal Article] Galectin-1 reduces the severity of herpes simplex virus-induced ocular immunopathological lesions (2012)
  • Author(s): Rajasagi NK
  • Journal Title: J Immunol Volume: 1;188(9) Issue: 9 Pages: 4631-43
  • DOI: 10.4049/jimmunol.1103063
  • Peer Reviewed
• [Journal Article] Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection (2012)
  • Author(s): Elahi S
  • Journal Title: Blood Volume: 3;119(18) Issue: 18 Pages: 4192-204
  • DOI: 10.1182/blood-2011-11-389585
  • Peer Reviewed
• [Journal Article] IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma (2012)
  • Author(s): Yang ZZ
  • Journal Title: J Clin Invest Volume: 2;122(4) Issue: 4 Pages: 1271-82
  • DOI: 10.1172/jci59806
  • Peer Reviewed
• [Journal Article] Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner (2012)
  • Author(s): Oomizu S
  • Journal Title: Clin Immunol Volume: 143(1) Issue: 1 Pages: 51-8
  • DOI: 10.1016/j.clim.2012.01.004
  • Peer Reviewed
• [Journal Article] Tim-3 is an inducible human NK cell receptor that enhances interferon gamma production in response to galectin-9 (2012)
  • Author(s): Gleason MK
  • Journal Title: Blood Volume: (印刷中) Issue: 13 Pages: 3064-72
  • DOI: 10.1182/blood-2011-06-360321
  • Peer Reviewed
• [Journal Article] Galectin-9 ameliorates herpes simplex virus-induced inflammation through apoptosis (2012)
  • Author(s): Shim JA
  • Journal Title: Immunobiology Volume: 217(6) Issue: 6 Pages: 657-66
  • DOI: 10.1016/j.imbio.2011.11.002
  • Peer Reviewed
• [Journal Article] Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages (2012)
  • Author(s): Kadowaki T
  • Journal Title: Clin Immunol Volume: 142(3) Issue: 3 Pages: 296-307
  • DOI: 10.1016/j.clim.2011.11.006
  • Peer Reviewed
• [Journal Article] Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection (2012)
  • Author(s): Shokrollah Elahi
  • Journal Title: Blood Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Galectin-9 ameliorates acute GVH disease through the induction of T-cell apoptosis (2011)
  • Author(s): Sakai K., Kawata E., Ashihara E., Nakagawa Y., Yamauchi A., Yao H., Nagao R., Tanaka R., Yokota A., Takeuchi M., Hirai H., Kimura S., Hirashima M., Yoshimura N., Maekawa T.
  • Journal Title: Eur J Immunol Volume: 41 Pages: 67-75
• [Journal Article] Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways. (2011)
  • Author(s): Vega-Carrascal I, Reeves EP, Niki T, Arikawa T, McNally P, O'Neill SJ, Hirashima M, McElvaney NG.
  • Journal Title: J. Immunol. Volume: 186 Pages: 2897-909
• [Journal Article] Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect. (2011)
  • Author(s): Iqbal AJ, Sampaio AL, Maione F, Greco KV, Niki T, Hirashima M, Perretti M, Cooper D.
  • Journal Title: Am. J. Pathol. Volume: 178 Pages: 1201-9
• [Journal Article] Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells. (2011)
  • Author(s): Lv K, Xu W, Wang C, Niki T, Hirashima M, Xiong S.
  • Journal Title: Clin Immunol Volume: 140 Pages: 92-101
• [Journal Article] Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. (2011)
  • Author(s): Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR.
  • Journal Title: Blood Volume: 117 Pages: 4501-10
• [Journal Article] Galectin-9 attenuates acute lung injury by expanding CD14- plasmacytoid dendritic cell-like macrophages. (2011)
  • Author(s): Kojima K, Arikawa T, Saita N, Goto E, Tsumura S, Tanaka R, Masunaga A, Niki T, Oomizu S, Hirashima M, Kohrogi H.
  • Journal Title: Am J Respir Crit Care Med Volume: 184 Pages: 328-39
• [Journal Article] Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency. (2011)
  • Author(s): Reddy PB, Sehrawat S, Suryawanshi A, Rajasagi NK, Mulik S, Hirashima M, Rouse BT
  • Journal Title: J Immunol Volume: 187 Pages: 5748-55
• [Journal Article] Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways (2011)
  • Author(s): Vega-Carrascal I
  • Journal Title: J.Immunol. Volume: 186 Issue: 5 Pages: 2897-2909
  • DOI: 10.4049/jimmunol.1003187
  • Peer Reviewed
• [Journal Article] Endogenous galectin-1 and acute inflammation : emerging notion of a galectin-9 pro-resolving effect (2011)
  • Author(s): Iqbal AJ
  • Journal Title: Am.J.Pathol. Volume: 178 Issue: 3 Pages: 1201-1209
  • DOI: 10.1016/j.ajpath.2010.11.073
  • Peer Reviewed
• [Journal Article] Cutting edge : critical role of intracellular osteopontin in antifungal innate immune responses (2011)
  • Author(s): Inoue M
  • Journal Title: J Immunol Volume: 186 Issue: 1 Pages: 19-23
  • DOI: 10.4049/jimmunol.1002735
  • Peer Reviewed
• [Journal Article] Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells (2011)
  • Author(s): Lv K
  • Journal Title: Clin Immunol Volume: 140 Issue: 1 Pages: 92-101
  • DOI: 10.1016/j.clim.2011.03.017
  • Peer Reviewed
• [Journal Article] Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia (2011)
  • Author(s): Zhou Q
  • Journal Title: Blood Volume: 117 Issue: 17 Pages: 4501-4510
  • DOI: 10.1182/blood-2010-10-310425
  • Peer Reviewed
• [Journal Article] Galectin-9 attenuates acute lung injury by expanding CD14-plasmacytoid dendritic cell-like macrophages (2011)
  • Author(s): Kojima K
  • Journal Title: Am J Respir Crit Care Med Volume: 184 Pages: 328-339
  • Peer Reviewed
• [Journal Article] Functional characterization of lipopolysaccharide derived from symbiotic bacteria in rice as a macrophage-activating substance (2011)
  • Author(s): Kadowaki T
  • Journal Title: Anticancer Res Volume: 31 Pages: 2467-2476
  • Peer Reviewed
• [Journal Article] Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency (2011)
  • Author(s): Reddy PB
  • Journal Title: J Immunol Volume: 187 Issue: 11 Pages: 5745-5755
  • DOI: 10.4049/jimmunol.1102105
  • Peer Reviewed
• [Journal Article] A novel IL-12-TIM-3 pathway induces T cell exhaustion and predicts reduced survival in patients with follicular B-cell non-Hodgkin lymphoma (2011)
  • Author(s): Zhi-Zhang Yang
  • Journal Title: J Clin Invest Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Galectin-9 ameliorates acute GVH disease through the induction of T-cell apoptosis. (2011)
  • Author(s): Sakai Kazuki
  • Journal Title: Eur J Immunol Volume: 41 Pages: 67-75
  • Peer Reviewed
• [Journal Article] Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways. (2011)
  • Author(s): Vega-Carrascal I
  • Journal Title: J Immunol Volume: 186 Pages: 2897-2909
  • Peer Reviewed
• [Journal Article] Co-expression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. (2011)
  • Author(s): Zhou Q
  • Journal Title: Blood Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Galectin-9 expands immunosuppressive macrophages to ameliorate T cell-mediated lung inflammation. (2010)
  • Author(s): Arikawa T, Saita N, Oomizu S, Ueno M, Matsukawa A, Katoh S, Kojima K, Nagahara K, Miyake M, Yamauchi A, Kohrogi H, and Hirashima M.
  • Journal Title: Eur J Immunol Volume: 40 Pages: 548-58
• [Journal Article] Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways (2010)
  • Author(s): T. Kobayashi, J. Kuroda, E.Ashihara, S. Oomizu, Y. Terui, A. Taniyama, S. Adachi, T. Takagi, M. Yamamoto, N Sasaki, S Horiike, K. Hatake, A. Yamauchi, M.Hirashima, M. Taniwaki.
  • Journal Title: Leukemia Volume: 24 Pages: 843-50
• [Journal Article] Galectin-9 induces osteoblast differentiaion through the CD44/Smad signaling pathway. (2010)
  • Author(s): R. Tanikawa, T.Tanikawa, M. Hirashima, A. Yamauchi, Y.Tanaka.
  • Journal Title: BBRC Volume: 394 Pages: 317-22
• [Journal Article] Targeting activating transcription factor 3 by galectin-9 induces apoptosis and overcomes various types of treatment resistance in chronic myelogenous leukemia. (2010)
  • Author(s): J. Kuroda, M.Yamamoto, H. Nagoshi, T. Kobayashi, N. Sasaki, Y Shimura, S Horiike, S. Kimura, A. Yamauchi, M. Hirashima, M.Taniwaki.
  • Journal Title: Molecular Cancer Research Volume: 8 Pages: 994-1001
• [Journal Article] Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells., Valerie Dardalhon, AC. Anderson (2010)
  • Author(s): J.Karman, L. Apetoh, R. Chandwaskar, DH. Lee, M.Cornejo, N. Nishi, A. Yamauchi, FJ. Quintana, RA. Sobel, M. Hirashima, VK. Kuchroo.
  • Journal Title: J. Immunol. Volume: 185 Pages: 1383-92
• [Journal Article] Galectin-9 trafficking regulates apical-basal polarity in Madin-Darby canine kidney epithelial cells. (2010)
  • Author(s): Rashmi Mishra, Michal Grzybek, Toshiro Niki, Mitsuomi Hirashima, Kai Simons.
  • Journal Title: PNAS Volume: 107 (41) Pages: 17633-38
• [Journal Article] A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in chronic hepatitis C infection. (2010)
  • Author(s): John A. Mengshol, Lucy Golden-Mason, Tomohiro Arikawa, Maxwell Smith, Toshiro Niki, Ryan McWilliams, Jessica Randall, Rachel McMahan, Manu Rangachari, Evgenia Dobrinskikh, Pierre Busson, Stephen J. Polyak, Mitsuomi Hirashima, Hugo R. Rosen.
  • Journal Title: Plos One Volume: 5(3)
• [Journal Article] Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8+ T cell response (2010)
  • Author(s): Sharvan Sehrawat, Pradeep B J Reddy, Naveen Rajasagi, Amol Suryawanshi, Mitsuomi Hirashima, Barry T Rouse.
  • Journal Title: PLOS Pathogens Volume: 6 (5)
• [Journal Article] Determination of carbohydratebinding preferences of human galectins with carbohydrate microarrays. (2010)
  • Author(s): T.Horlacher, M A. Oberli, DB. Werz, LH. Krock, S. Bufali, B. Stocker, R. Mishra, J. Sobek, K. Simons, M. Hirashima, T. Niki, PH. Seeberger.
  • Journal Title: ChemBioChem Volume: 11 Pages: 1563-73
• [Journal Article] X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose (2010)
  • Author(s): H. Yoshida, M. Teraoka, N. Nishi, S. Nakakita, T. Nakamura, M.Hirashima. S. Kamitori.
  • Journal Title: J Biol Chem Volume: 285 Pages: 36969-76
• [Journal Article] Galectin-9 expands immunosuppressive macrophages to ameliorate T cell-mediated lung inflammation. (2010)
  • Author(s): Tomohiro Arikawa
  • Journal Title: Eur J Immunol Volume: 40 Pages: 548-558
  • Peer Reviewed
• [Journal Article] Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways. (2010)
  • Author(s): Tsutomu Kobayashi
  • Journal Title: Leukemia Volume: 24 Pages: 843-850
  • Peer Reviewed
• [Journal Article] Galectin-9 induces osteoblast differentiaion through the CD44/Smad signaling pathway. (2010)
  • Author(s): Rena Tanikawa
  • Journal Title: BBRC Volume: 394 Pages: 317-322
  • Peer Reviewed
• [Journal Article] Involvement of galectin-9 in lung eosinophilia in patients with eosinophilic pneumonia. (2010)
  • Author(s): Shigeki Katoh
  • Journal Title: Int Arch Allergy Immunol Volume: 153 Pages: 294-302
  • Peer Reviewed
• [Journal Article] Preparation of lipopolysaccharide derived from Pantoea agglomerans labeled with fluorescence as a tracer for kinetics analysis. (2010)
  • Author(s): Takeshi Kadowaki
  • Journal Title: Anticancer Res Volume: 30 Pages: 3151-3157
  • Peer Reviewed
• [Journal Article] Tim-3/galectin-9 pathway : regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. (2010)
  • Author(s): Valerie Dardalhon
  • Journal Title: J Immunol. Volume: 185 Pages: 1383-1392
  • Peer Reviewed
• [Journal Article] Galectin-9 trafficking regulates apical-basal polarity in Madin-Darby canine kidney epithelial cells. (2010)
  • Author(s): Rashmi Mishra
  • Journal Title: PNAS Volume: 107 Pages: 17633-17638
  • Peer Reviewed
• [Journal Article] A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in chronic hepatitis C infection. (2010)
  • Author(s): John A.Mengshol
  • Journal Title: Plos One Volume: 5
  • Peer Reviewed
• [Journal Article] Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8+ T cell response. (2010)
  • Author(s): Sharvan Sehrawat
  • Journal Title: PLOS Pathogens Volume: 6
  • Peer Reviewed
• [Journal Article] Determination of carbohydrate-binding preferences of human galectins with carbohydrate microarrays. (2010)
  • Author(s): Tim Horlacher
  • Journal Title: ChemBioChem Volume: 11 Pages: 1563-1573
  • Peer Reviewed
• [Journal Article] The increase of plasma galectin-9 in a patient with insulin allergy : a casereport. (2010)
  • Author(s): Haorile Chagan-Yasutan
  • Journal Title: Clin Mol Allergy Volume: 8 Pages: 1-4
  • Peer Reviewed
• [Journal Article] X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose. (2010)
  • Author(s): Hiromi Yoshida
  • Journal Title: J Biol Chem Volume: 285 Pages: 36969-36976
  • Peer Reviewed
• [Journal Article] Endogenous galectin-1 and acute inflammation : emerging notion of agalectin-9 pro-resolving effect. (2010)
  • Author(s): Iqbal AJ
  • Journal Title: Am J Pathol Volume: 178 Pages: 1201-1209
  • Peer Reviewed
• [Presentation] Critical role of galectin-9 but not IL-10 from Typel regulatory T cells to regulate T helper 17 cell development (2011)
  • Author(s): 大水総一
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-27
• [Presentation] Galectin-9 switches monocyte differentiation to plasmacytoid dendritic cell-like macrophages to prolong the survival of lung cancer-bearing mice (2011)
  • Author(s): 門脇健
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-27
• [Presentation] 安定化ガレクチン9:抗感染活性を有する免疫正常化因子の開発 (2011)
  • Author(s): 平島光臣
  • Organizer: B型肝炎Reactivationセミナー
  • Place of Presentation: 東京国際フォーラム(東京都)(招待講演)
  • Year and Date: 2011-09-05
• [Presentation] 安定化ガレクチン9の開発と自己免疫疾患モデルでの有効性 (2011)
  • Author(s): 仁木敏朗
  • Organizer: 国際バイオEXPO(バイオアカデミックフォーラム)
  • Place of Presentation: 東京ビッグサイト(東京都)
  • Year and Date: 2011-07-01
• [Presentation] Galectin-9 is an important conductor in innate and adaptive immunity (2011)
  • Author(s): 平島光臣
  • Organizer: 第10回オステオポンチン研究会
  • Place of Presentation: 北海道大学(札幌市)(招待講演)
  • Year and Date: 2011-06-18
• [Presentation] Galectin-9 in autoimmune pancreatitis and pancreatic cancer. (2010)
  • Author(s): Mitsuomi Hirashima
  • Organizer: 18th Yonsei International Gastroenterology Symposium
  • Place of Presentation: Yonsei University Health System(韓国)(招待講演)
  • Year and Date: 2010-12-04
• [Presentation] Galectin-9とTim-3による免疫制御機構について (2010)
  • Author(s): 平島光臣
  • Organizer: 東京医科歯科大学大学院
  • Place of Presentation: 東京医科歯科大学大学院(東京都)(招待講演)
  • Year and Date: 2010-10-26
• [Presentation] ガレクチン9とマクロファージ (2010)
  • Author(s): 平島光臣
  • Organizer: 第9回四国免疫フォーラム
  • Place of Presentation: 愛媛大学医学部(愛媛県)
  • Year and Date: 2010-06-19
• [Presentation] Galectin-9 beneficially modulates macrophage functions in inflammation and cancer. (2010)
  • Author(s): Mitsuomi Hirashima
  • Organizer: 18th International Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: くまもと県民交流館パレア(熊本県)(招待講演)
  • Year and Date: 2010-05-20
• [Presentation] Crystal structure of the C-terminal carbohydrate recognition domain of human galectin-9 (2010)
  • Author(s): Hiromi Yoshida
  • Organizer: 35th FEBS Congress
  • Place of Presentation: Gothenburg(Sweden)
• [Presentation] ヒト由来ガレクチン9のC末端糖鎖認識ドメイン・シアリルラクトース複合体およびプロテアーゼ耐性型ヒト由来ガレクチン8のX線結晶解析 (2010)
  • Author(s): 吉田裕美
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
• [Presentation] Galectin-9 down-regulates Th17 cell differentiation independently of Tim-3/Galectin-9 interaction. (2010)
  • Author(s): Souichi Oomizu
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸ポートピアホテル、神戸国際展示場(兵庫県)
• [Presentation] X-ray Structure of Galectin-9 C-terminal Domain in Complex with (2010)
  • Author(s): Shigehiro Kamitori
  • Organizer: The 25th International Carbohydrate Symposium(ICS2010)
  • Place of Presentation: 幕張メッセ(千葉県)