| Project/Area Number |
22590717
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Takashi 東京大学, 医学部附属病院, 助教 (10569106)
伊地知 秀明 東京大学, 医学部附属病院, 助教 (70463841)
池上 恒雄 東京大学, 医科学研究所, 准教授 (80396712)
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| Co-Investigator(Renkei-kenkyūsha) |
IKENOUE Tsuneo 東京大学, 医科学研究所, 准教授 (80396712)
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| Research Collaborator |
IJICHI Hideaki 東京大学, 医学部附属病院, 助教 (70463841)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 胆管癌 / マウスモデル / 肝癌 / 細胞内シグナル伝達 / 肝臓学 / 肝内胆管癌 |
|---|
| Research Abstract |
We generated hepatic cancer mouse model by inducing expression of activated Kras and ablation of Pten under albumin-promoter. The mice died from multipe liver tumor in 7 to 8 weeks. Using genomic analysis of SNP array, we found that Hippo pathway, a novel intracellular signaling, was involved in hepatocarcinogenesis. Aberration of SAV1, a component of the pathway, was shown to induce the activation of YAP/TAZ and following expression of CTGF in a liver cancer cell line.
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