| Project/Area Number |
22590849
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
TANABE Nobuhiro 千葉大学, 大学院・医学研究院, 准教授 (40292700)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAKAO Seiichiro 千葉大学, 医学部附属病院, 助教 (80431740)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Akinori 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
NAKANISHI Norihumi 独立行政法人国立循環器病研究センター, 心臓内科, 部長 (80164234)
KASAHARA Yasunori 千葉大学, 医学部附属病院, 講師 (60343092)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 肺高血圧症 / 遺伝薬 / オーダーメード医療 / 右心機能 / 慢性血栓塞栓性肺高血圧症 / 肺動脈性肺高血圧症 / 遺伝薬理学 / オーダーメード治療 / 慢性血栓塞栓性肺高 / 肺動脈性肺高血圧 |
|---|
| Research Abstract |
The purpose of this study is to elucidate genetic factors associated with response to therapy for pulmonary arterial hypertension in order to establish personalized therapy in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension, and also to find genetic factors related to right heart failure and prognosis. We found that time to clinical worsening after sildenafil was significantly shorter in the patients having combination of CC/CT genotypes of G protein)3 3 subunit gene (GNB3) polymorphism and deletion/deletion genotypes of ACE gene polymorphism. Neither GNB3 nor ACE gene polymorphisms were related to response to bosentan. The CC genotype of NOS 786C/T polymorphism predicted right heart failure. In CTEPH, combination of having T allele of Endothelin-1 lys198Asp(G/T) and TT genotypes of endothelin A receptor H323H (C/T) polymorphisms predicted poor prognosis.
|
