Analysis of cell differentiation machinery regulated by ATM
| Project/Area Number |
22591121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
PIAO Jinhua 東京医科歯科大学, 大学院・医歯学総合研究科, メディカルフェロー (70567750)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Masatoshi 東京医科歯科大学, 大学院・, 講師 (10406267)
SUGIMOTO Masataka 国立長寿医療センター, 研究所, プロジェク トリーダー (50426491)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 小児腫瘍学 / PARP阻害剤 / 急性リンパ性白血病 / ＡＴＭ / 細胞分化 / 毛細血管拡張性運動失調症 / 脂肪細胞 / microRNA / iPS細胞 / 神経幹細胞 / ATM / C/EBPα / T細胞受容体 |
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| Research Abstract |
Adipocyte differentiation and lymphocyte differentiation is attenuated in Ataxia Telangiectasia. ATM is essential for cellular differentiation machinery. Differentiation disorder is due to histone acetylation deficiency or discordance of genomic repair and cell cycle regulation.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM2012
Author(s)
Isoda T, Takagi M, Piao J, Nakagama S,Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
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Journal Title
Blood
Volume: 120(4)
Issue: 4
Pages: 789-9
DOI
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Peer Reviewed
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[Presentation] Visualization of chromosomal translocation and early T-cell development failure in ATM deficiency2012
Author(s)
Isoda T, Takagi, M, Piao J, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
Organizer
14th International workshop on AtaxiaTelangiectasia
Place of Presentation
Delhi, India
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[Presentation] T-Cell Development Failure At β-Selection Checkpoint and TCRα/δ Locus Break Formation Associated with Chromosome 14Translocation in Ataxia-Telangiectagia Mutated Deficient Mice2011
Author(s)
Isoda T, Takagi M, Piao J, Nakagama S, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
Organizer
53^<rd> American society of hematology, annual meeting
Place of Presentation
San Diego
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