Analysis of cell differentiation machinery regulated by ATM

• Project/Area Number: 22591121
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: PIAO Jinhua 東京医科歯科大学, 大学院・医歯学総合研究科, メディカルフェロー (70567750)
• Co-Investigator(Kenkyū-buntansha): TAKAGI Masatoshi 東京医科歯科大学, 大学院・, 講師 (10406267) ; SUGIMOTO Masataka 国立長寿医療センター, 研究所, プロジェク トリーダー (50426491)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 小児腫瘍学 / PARP阻害剤 / 急性リンパ性白血病 / ＡＴＭ / 細胞分化 / 毛細血管拡張性運動失調症 / 脂肪細胞 / microRNA / iPS細胞 / 神経幹細胞 / ATM / C/EBPα / T細胞受容体

Research Abstract

Adipocyte differentiation and lymphocyte differentiation is attenuated in Ataxia Telangiectasia. ATM is essential for cellular differentiation machinery. Differentiation disorder is due to histone acetylation deficiency or discordance of genomic repair and cell cycle regulation.

Research Products

• [Journal Article] Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM (2012)
  • Author(s): Isoda T, Takagi M, Piao J, Nakagama S,Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
  • Journal Title: Blood Volume: 120(4) Issue: 4 Pages: 789-9
  • DOI: 10.1182/blood-2012-02-413195
  • Peer Reviewed
• [Journal Article] 毛細血管拡張性運動失調症Ataxia Telangiectasiaと関連疾患 (2012)
  • Author(s): 高木正稔
  • Journal Title: メディカル・サイエンス・ダイジェスト Volume: 38(1) Pages: 17-20
• [Journal Article] AtaxiaTelangiectasiaにおけるミトコンドリア異常 (2012)
  • Author(s): 金子節子,高木正稔
  • Journal Title: 血液内科 Volume: 65(6) Pages: 825-31
  • NAID: 40019555246
• [Journal Article] Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation (2011)
  • Author(s): Nakamura H,Kawagishi H,Watanabe A, Sugimoto K, Maruyama M, Sugimoto M
  • Journal Title: Mol Cell Biol Volume: 31 Issue: 10 Pages: 101997-2009
  • DOI: 10.1128/mcb.01424-10
  • Peer Reviewed
• [Journal Article] Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation (2011)
  • Author(s): Takagi M, 他
  • Journal Title: Blood Volume: 117 Pages: 2887-2892
  • Peer Reviewed
• [Journal Article] Activation of the Activin A-ALK-Smad Pathway in Systemic Sclerosis (2011)
  • Author(s): Takagi K, 他
  • Journal Title: J Autoimmunity Volume: 26 Pages: 181-188
  • Peer Reviewed
• [Journal Article] DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. (2010)
  • Author(s): Ichijima Y
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites. (2010)
  • Author(s): Kobori H
  • Journal Title: Immunology Volume: 130 Pages: 363-373
  • Peer Reviewed
• [Journal Article] T ranscription-dependent activation of ataxia telangiectasia-mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison (2010)
  • Author(s): Sakasai R
  • Journal Title: J Biol Chem Volume: 285 Pages: 15201-152018
  • Peer Reviewed
• [Journal Article] ARF Suppresses Tumor Angiogenesis thorough Translational Control of VEGF mRNA (2010)
  • Author(s): Kawagishi H
  • Journal Title: Cancer Res Volume: 70 Pages: 4749-4758
  • Peer Reviewed
• [Journal Article] Pharmacokinetic monitoring is still required for intravenous busulfan in SCT for small children (2010)
  • Author(s): Nagasawa M
  • Journal Title: Int J Hematol. Volume: 91 Pages: 728-730
  • Peer Reviewed
• [Journal Article] Attenuation of p53 accumulation after irradiation in cells with C465T polymorphism (2010)
  • Author(s): Sato M
  • Journal Title: J Med Dent Sci Volume: 57 Pages: 139-145
  • Peer Reviewed
• [Journal Article] Autopsy study of cerebellar degeneration in siblings with ataxia-telangiectasia-like disorder (2010)
  • Author(s): Oba D
  • Journal Title: Acta Neuropathol Volume: 119 Pages: 513-20
  • Peer Reviewed
• [Journal Article] Autoimmune phenomena in Noonan syndrome : a possible link with RALD (2010)
  • Author(s): Mizutani S
  • Journal Title: Blood
  • Peer Reviewed
• [Presentation] Derivation of neural stem cell via iPS from Ataxia Telangiectasia (2012)
  • Author(s): 金子節子
  • Organizer: Ataxia Telangiectasia International workshop 2012
  • Place of Presentation: インド・ニューデリー
  • Year and Date: 2012-02-07
• [Presentation] Derivation of neural stem cell via iPS cell from ataxia telangiectasia (2012)
  • Author(s): Kaneko S, Takagi M, Fukawatase Y, Umezawa A, Mizutani S
  • Organizer: 14th International workshop on Ataxia Telangiectasia
  • Place of Presentation: Delhi, India
• [Presentation] Visualization of chromosomal translocation and early T-cell development failure in ATM deficiency (2012)
  • Author(s): Isoda T, Takagi, M, Piao J, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
  • Organizer: 14th International workshop on AtaxiaTelangiectasia
  • Place of Presentation: Delhi, India
• [Presentation] ATM欠損T細胞分化のDN期におけるTリンパ球減少の原因と染色体転座の関係 (2012)
  • Author(s): 磯田健志,高木正稔,朴今花,増田喬子,伊川友活,東みゆき,森尾友宏,河本宏,水谷修紀
  • Organizer: 第115回日本小児科学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 毛細血管拡張性小脳失調症(AtaxiaTelangiectagia)におけるT細胞分化異常の解析 (2011)
  • Author(s): 磯田健志,高木正稔,森尾友宏,水谷修紀
  • Organizer: 日本臨床免疫学会会誌
• [Presentation] DN3 T-cell development failurein Ataxia telangiectagia (AT) (2011)
  • Author(s): Isoda T, Takagi M, Piao J, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] 毛細血管運動失調症の Double Negative 期におけるT リンパ球分化異常と発がんメカニズムの関係 (2011)
  • Author(s): 磯田健志,高木正稔,朴今花,増田喬子,井川友活,東みゆき,森尾友宏,河本宏,水谷修紀
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
• [Presentation] T-Cell Development Failure At β-Selection Checkpoint and TCRα/δ Locus Break Formation Associated with Chromosome 14Translocation in Ataxia-Telangiectagia Mutated Deficient Mice (2011)
  • Author(s): Isoda T, Takagi M, Piao J, Nakagama S, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
  • Organizer: 53^<rd> American society of hematology, annual meeting
  • Place of Presentation: San Diego
• [Presentation] ATM regulates adiopocyte differentiation (2010)
  • Author(s): 烏野初萌
  • Organizer: 第33回分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] ATM regulates cell differentiation (2010)
  • Author(s): Masatoshi Takagi
  • Organizer: 第33回分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] T細胞リンパ腫とAtmハプロ不全～BCRABLトランスジェニックマウスを用いた解析 (2010)
  • Author(s): 佐藤正樹
  • Organizer: 第33回分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] RAS associated ALPS like disease (2010)
  • Author(s): 高木正稔
  • Organizer: 関東甲越免疫不全症研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-23
• [Presentation] DNA損傷応答機構と白血病 (2010)
  • Author(s): 高木正稔
  • Organizer: 第53回日本放射線影響学会大会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-20
• [Presentation] ATM regulates adiopocyte differentiation (2010)
  • Author(s): Masatoshi Takagi
  • Organizer: ATW2010
  • Place of Presentation: Los Angels(米国)
  • Year and Date: 2010-04-11
• [Presentation] DNA複製障害時の重傷複合型免疫不全症責任遺伝子Artemisの持つ役割についての解析 (2010)
  • Author(s): 高木正稔
  • Organizer: 第3回日本免疫不全症研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-30
• [Presentation] KRAS変異を持つALPS様疾患の1例-Is there any sequentiality between ALPS and JMML (2010)
  • Author(s): 高木正稔
  • Organizer: 第17回小児再生不良性貧血治療研究会、第15回小児MDS治療研究会
  • Place of Presentation: 名古屋
• [Presentation] A novel method to analyze genomic copy number of Diamond Blacfan anemia responsible gene (2010)
  • Author(s): Madoka Kuramitsu
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
• [Presentation] KRAS変異自己免疫性リンパ球増殖症候群 (2010)
  • Author(s): 高木正稔
  • Organizer: 第52回日本小児血液学会・第26回日本小児がん学会総会
  • Place of Presentation: 大阪
• [Presentation] T細胞リンパ腫とAtmハプロ不全～BCRABLトランスジェニックマウスを用いた解析 (2010)
  • Author(s): 佐藤正樹
  • Organizer: 第52回日本小児血液学会・第26回日本小児がん学会総会
  • Place of Presentation: 大阪