The role of beta 7 integrin on cutaneous cell infiltration and melanoma

• Project/Area Number: 22591217
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: The University of Tokyo
• Principal Investigator: KADONO Takafumi 東京大学, 医学部附属病院, 准教授 (80292910)
• Co-Investigator(Kenkyū-buntansha): SATO Shinichi 東京大学, 医学部附属病院, 教授 (20215792)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 皮膚腫瘍学 / beta 7 integrin / alpha E integrin / 悪性黒色腫 / ICAM-1 / VCAM-1 / beta7インテグリン

Research Abstract

As leukocyte infiltration is one of the most important factors for tumor immunity in melanoma, we investigated the role of beta 7 integrin and alpha E integrin that belong to adhesion molecules implicated in leukocyte migration. The lack of alpha E integrin did not affect tumor immunity, whereas beta 7 integrin deficiency significantly augmented the tumor immunity. When beta 7 integrin is deficient, the expressions of ICAM-1 and VCAM-1 were upregulated to compensate for the loss of beta 7 integrin, which lead to the increase of Th1-type CD4-positive T cells which produced significant amount of interferon gamma.

Research Products

• [Journal Article] CCR10 and CCL27 are overexpressed in cutaneous squamous cell carcinoma. (2011)
  • Author(s): Kai H, Kadono T, Kakinuma T, Tomita M, Ohmatsu H, Asano Y, Tada Y, Sugaya M, Sato S
  • Journal Title: Pathol Res Pract Volume: 207 Pages: 43-48
• [Journal Article] α4β7 integrin is essential for contact hypersensitivity by regulating migration of T cells to inflammatory skin. (2010)
  • Author(s): Ohmatsu H,Kadono T,Sugaya M,Tomita M, Kai H, Saeki H,Steeber DA,Tedder TF,Tamaki K,SatoS
  • Journal Title: J Allergy Clin Immun Volume: 126 Pages: 1267-1276
• [Journal Article] 皮膚の炎症における細胞接着分子の役割 (2010)
  • Author(s): 門野岳史
  • Journal Title: 日本臨床免疫学会会誌 Volume: 33(5) Pages: 242-248
  • NAID: 10027753863
• [Presentation] β 7 integrin deficiency attenuates immune complex-mediated tissue injury. (2012)
  • Author(s): Yamada D, Kadono T, Masui Y, Asano Y, Tada Y Sugaya M, Sato S
  • Organizer: 42st Annual Meeting of the European Society for Dermatological Research Meeting
  • Place of Presentation: Venice, Italy.
• [Presentation] α E integrin deficiency attenuates Arthus reaction. (2012)
  • Author(s): Yamada D, Kadono T, Masui Y, Asano Y, Tada Y, Sugaya M, Sato S
  • Organizer: 第37回日本研究皮膚科学会年次学術大会・総会
  • Place of Presentation: 那覇
• [Presentation] β7 integrin deficiency attenuates immune complex-mediated tissue injury (2012)
  • Author(s): Yamada D, Kadono T, Masui Y, Asano Y, Tada Y Sugaya M, Sato S
  • Organizer: Annual Meeting of the European Society for Dermatological Research Meeting
  • Place of Presentation: Venice, Italy
• [Presentation] Beta 7 integrin is essential for the induction of oral tolerance. (2011)
  • Author(s): Kadono T, Ohmatsu H, Sato S
  • Organizer: Immunology2011 The Annual Meeting of the American Association of Immunologists
  • Place of Presentation: San Francisco, USA.
• [Presentation] CXC chemokine receptor 3 deficiency promotes cutaneous tumor formation. (2011)
  • Author(s): Masui Y, Kadono T, Kai H, Sato S
  • Organizer: Immunology2011 The Annual Meeting of the American Association of Immunologists
  • Place of Presentation: San Francisco, USA.
• [Presentation] CXC chemokine receptor 3 deficiency promotes cutaneous tumor formation (2011)
  • Author(s): Masui Y, Kadono T, Kai H, Sato S
  • Organizer: Immunology2011 The Annual Meeting of the American Association of Immunologists
  • Place of Presentation: San Francisco, USA
• [Presentation] β 7 integrin and cutaneous inflammation. (2010)
  • Author(s): Kadono T
  • Organizer: La Jolla Institute for Allergy & Immunology (LIAI) Immunology Symposium
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2010-11-08
• [Presentation] 悪性黒色腫に対する beta7 integirn の役割 (2010)
  • Author(s): 門野岳史
  • Organizer: 平成 22年度厚生労働省「悪性黒色腫に対する新しい診療体系の確立に 関する研究」研究班第1回班会議
  • Place of Presentation: 東京
  • Year and Date: 2010-07-31
• [Presentation] Beta7 integrin deficiency suppress cutaneous tumor formation. (2010)
  • Author(s): Kai H, Kadono T, Ohmatsu H, Tomita M, Asano Y, Sugaya M, Sato S
  • Organizer: Immunology2010 The Annual Meeting of the American Association of Immunologists May
  • Place of Presentation: Baltimore, USA.
  • Year and Date: 2010-07-11
• [Presentation] β7 インテグリンと皮膚 (2010)
  • Author(s): 門野岳史
  • Organizer: 第1回東京Immunology Club for Young Dermatologists研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-02-06