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The role of beta 7 integrin on cutaneous cell infiltration and melanoma

Research Project

Project/Area Number 22591217
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionThe University of Tokyo

Principal Investigator

KADONO Takafumi  東京大学, 医学部附属病院, 准教授 (80292910)

Co-Investigator(Kenkyū-buntansha) SATO Shinichi  東京大学, 医学部附属病院, 教授 (20215792)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords皮膚腫瘍学 / beta 7 integrin / alpha E integrin / 悪性黒色腫 / ICAM-1 / VCAM-1 / beta7インテグリン
Research Abstract

As leukocyte infiltration is one of the most important factors for tumor immunity in melanoma, we investigated the role of beta 7 integrin and alpha E integrin that belong to adhesion molecules implicated in leukocyte migration. The lack of alpha E integrin did not affect tumor immunity, whereas beta 7 integrin deficiency significantly augmented the tumor immunity. When beta 7 integrin is deficient, the expressions of ICAM-1 and VCAM-1 were upregulated to compensate for the loss of beta 7 integrin, which lead to the increase of Th1-type CD4-positive T cells which produced significant amount of interferon gamma.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2012 2011 2010

All Journal Article (3 results) Presentation (10 results)

  • [Journal Article] CCR10 and CCL27 are overexpressed in cutaneous squamous cell carcinoma.2011

    • Author(s)
      Kai H, Kadono T, Kakinuma T, Tomita M, Ohmatsu H, Asano Y, Tada Y, Sugaya M, Sato S
    • Journal Title

      Pathol Res Pract

      Volume: 207 Pages: 43-48

    • Related Report
      2012 Final Research Report
  • [Journal Article] α4β7 integrin is essential for contact hypersensitivity by regulating migration of T cells to inflammatory skin.2010

    • Author(s)
      Ohmatsu H,Kadono T,Sugaya M,Tomita M, Kai H, Saeki H,Steeber DA,Tedder TF,Tamaki K,SatoS
    • Journal Title

      J Allergy Clin Immun

      Volume: 126 Pages: 1267-1276

    • Related Report
      2012 Final Research Report
  • [Journal Article] 皮膚の炎症における細胞接着分子の役割2010

    • Author(s)
      門野岳史
    • Journal Title

      日本臨床免疫学会会誌

      Volume: 33(5) Pages: 242-248

    • NAID

      10027753863

    • Related Report
      2012 Final Research Report
  • [Presentation] β 7 integrin deficiency attenuates immune complex-mediated tissue injury.2012

    • Author(s)
      Yamada D, Kadono T, Masui Y, Asano Y, Tada Y Sugaya M, Sato S
    • Organizer
      42st Annual Meeting of the European Society for Dermatological Research Meeting
    • Place of Presentation
      Venice, Italy.
    • Related Report
      2012 Final Research Report
  • [Presentation] α E integrin deficiency attenuates Arthus reaction.2012

    • Author(s)
      Yamada D, Kadono T, Masui Y, Asano Y, Tada Y, Sugaya M, Sato S
    • Organizer
      第37回日本研究皮膚科学会年次学術大会・総会
    • Place of Presentation
      那覇
    • Related Report
      2012 Final Research Report
  • [Presentation] β7 integrin deficiency attenuates immune complex-mediated tissue injury2012

    • Author(s)
      Yamada D, Kadono T, Masui Y, Asano Y, Tada Y Sugaya M, Sato S
    • Organizer
      Annual Meeting of the European Society for Dermatological Research Meeting
    • Place of Presentation
      Venice, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] Beta 7 integrin is essential for the induction of oral tolerance.2011

    • Author(s)
      Kadono T, Ohmatsu H, Sato S
    • Organizer
      Immunology2011 The Annual Meeting of the American Association of Immunologists
    • Place of Presentation
      San Francisco, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] CXC chemokine receptor 3 deficiency promotes cutaneous tumor formation.2011

    • Author(s)
      Masui Y, Kadono T, Kai H, Sato S
    • Organizer
      Immunology2011 The Annual Meeting of the American Association of Immunologists
    • Place of Presentation
      San Francisco, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] CXC chemokine receptor 3 deficiency promotes cutaneous tumor formation2011

    • Author(s)
      Masui Y, Kadono T, Kai H, Sato S
    • Organizer
      Immunology2011 The Annual Meeting of the American Association of Immunologists
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] β 7 integrin and cutaneous inflammation.2010

    • Author(s)
      Kadono T
    • Organizer
      La Jolla Institute for Allergy & Immunology (LIAI) Immunology Symposium
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2010-11-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 悪性黒色腫に対する beta7 integirn の役割2010

    • Author(s)
      門野岳史
    • Organizer
      平成 22年度厚生労働省「悪性黒色腫に対する新しい診療体系の確立に 関する研究」研究班第1回班会議
    • Place of Presentation
      東京
    • Year and Date
      2010-07-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Beta7 integrin deficiency suppress cutaneous tumor formation.2010

    • Author(s)
      Kai H, Kadono T, Ohmatsu H, Tomita M, Asano Y, Sugaya M, Sato S
    • Organizer
      Immunology2010 The Annual Meeting of the American Association of Immunologists May
    • Place of Presentation
      Baltimore, USA.
    • Year and Date
      2010-07-11
    • Related Report
      2012 Final Research Report
  • [Presentation] β7 インテグリンと皮膚2010

    • Author(s)
      門野岳史
    • Organizer
      第1回東京Immunology Club for Young Dermatologists研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-06
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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