Effect of valproic acid and low dose docetaxel for radiosensitivity in esophageal squamous cell carcinoma
| Project/Area Number |
22591380
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMURA Takashi 金沢大学, 医学系, 准教授 (50262580)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 放射線治療学 / 食道癌 / 化学放射線療法 / バルプロ酸 / DNA二重鎖切断 / ドセタキセル / HDAC阻害剤 / DNA二重鎖切断修復酵素 |
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| Research Abstract |
We evaluated the Effect of valproic acid (VPA) and low dose docetaxel (DTX) for radiosensitivity in esophageal squamous cell carcinoma (ESCC). VPA induced acetylation of histones H3 and H4 in ESCC cells. VPA inhibited the DNA double strand break repair by decreasing Rad51 expression and Ku70 acetylation. VPA enhances ESCC cells radiosensitivity by chromatin decondensation and down regulation of DNA double strand break repair proteins. Low dose (5 nM) DTX induced G1 and G2-M accumulation in ESCC cell, respectively. Low dose DTX (
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Report
(4 results)
Research Products
(7 results)
