• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

EMT including cancer stem cells regulates invasion and metastasis of uterine endometrial cancer.

Research Project

Project/Area Number 22591869
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOsaka Medical College

Principal Investigator

TERAI Yoshito  大阪医科大学, 医学部, 准教授 (90278531)

Co-Investigator(Kenkyū-buntansha) OHMICHI Masahide  大阪医科大学, 医学部, 教授 (10283764)
TANABE Akiko  大阪医科大学, 医学部, 助教 (70454543)
KANEMURA Masanori  大阪医科大学, 医学部, 講師 (40298782)
SASAKI Hiroshi  大阪医科大学, 医学部, 助教 (80432491)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords子宮内膜癌 / 幹細胞 / EMT / 薬剤耐性 / 浸潤・転移 / 癌幹細胞 / CD24 / Snail / E-cadherin / 婦人科癌 / E-chadherin / Epithelial Mesenchymal Transition / E-cadherino / Slug / EMT現象
Research Abstract

E-cadherin and nuclear expression of Snail and Slug have a prognositic impact in endometrial cancer. CD24 correlated with EMT status in endometrial cancer. Therefore, to clarify and control of EMT signaling is a promising molecular targeting therapy inendometrial cancer.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2013 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (9 results)

  • [Journal Article] impact of EMT(Epithelial-Mesenchymal-Transition)related protein expression in endometrial cancer.2013

    • Author(s)
      Tanaka Y, Terai Y*, Yoo S, Tsunetoh S, Kanemura M, Tanabe A, Ohmichi M. Prognostic
    • Journal Title

      Cancer Biol Ther

      Volume: 14(1) Pages: 13-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] Prognostic impact of EMT (epithelial Mesenchymal-Trasition) related protein expression in endometrial cancer2013

    • Author(s)
      Yoshimichi Tanaka
    • Journal Title

      Cancer Biol Ther

      Volume: 14(1) Issue: 1 Pages: 13-19

    • DOI

      10.4161/cbt.22625

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian cancer.2011

    • Author(s)
      Tanaka Y, Terai Y*, Tanabe A, Sasaki H, Sekijima T, Fujiwara S, Yamashita Y, Kanemura M, Ueda M, Sugita M, Franklin WA, Ohmichi M.
    • Journal Title

      Cancer Biol Ther

      Volume: 11 Pages: 50-57

    • Related Report
      2012 Final Research Report
  • [Journal Article] Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of At and ERK in ovarian cancer.2011

    • Author(s)
      Yishimichi Tanaka
    • Journal Title

      Cancer Biology & Therapy

      Volume: 11(1) Pages: 50-57

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topotecan as a molecular targeting agent which blocks the At and VEGF cascade in platinum-resistant ovarian cancers.2010

    • Author(s)
      Tsunetoh Satoshi
    • Journal Title

      Cancer Biol Ther

      Volume: 10(11) Pages: 1137-1146

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mature cystic teratoma of the fallopian tube.2010

    • Author(s)
      Satoe Fujiwara
    • Journal Title

      Fertility and Sterility

      Volume: 94(7) Pages: 2708-2709

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 子宮体癌におけるEMTのマーカーとしてのCD24の有用性2012

    • Author(s)
      田中良道
    • Organizer
      第64回日本産科婦人科学会
    • Place of Presentation
      神戸、ポートピアホテル/神戸国際展示場
    • Year and Date
      2012-04-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮体癌における EMT のマーカーとしての CD24 の有用性2012

    • Author(s)
      田中良道、寺井義人、斎藤奈津穂、川口 浩史、中村路彦、兪 史夏、藤原聡枝、 佐々木浩、恒遠啓示、金村昌徳、田辺晃 子、大道正英
    • Organizer
      第64回日本産科婦人科学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] prognostic impact of EMepithelial-mesenchymal-transition)re lated protein expression in endometrial cancer2012

    • Author(s)
      田中良道、寺井義人、川口浩史、高井雅 聡、藤原聡枝、兪史夏、恒遠啓示、佐々 木浩、金村昌徳、田辺晃子、大道正英
    • Organizer
      2012 AmericanAssociation for Cancer Research
    • Place of Presentation
      Chicago、USA
    • Related Report
      2012 Final Research Report
  • [Presentation] prognostic impact of EMT (epithelial-mesenchymal-trasition) related prtein expression in endometrial cancer2012

    • Author(s)
      寺井義人
    • Organizer
      American Association for Cancer Research 2012 annual meeting
    • Place of Presentation
      Chicago
    • Related Report
      2012 Annual Research Report
  • [Presentation] 子宮体癌におけるEMTのマーカーとしてのCD24の有用性2012

    • Author(s)
      田中良道
    • Organizer
      第64回日本産科婦人科学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 婦人科癌の浸潤転移におけるEMT (Epithelial Mesenchymal Transition)の意義とEMT制御のターゲットとした新規治療の基礎的研究2012

    • Author(s)
      寺井義人
    • Organizer
      第53回日本婦人科腫瘍学会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] 子宮体癌における癌幹細胞やEMTの指標としてのCD24は有用か?2011

    • Author(s)
      田中良道
    • Organizer
      第49回日本癌治療学会
    • Place of Presentation
      名古屋、名古屋国際会議場
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 婦人科癌と EMT(epithelial mesenchymal transition)」Frontiers in Gynecologic Oncology2011

    • Author(s)
      寺井義人 、田中良道、川口浩史、兪史夏、 藤原聡枝、高井雅聡、恒遠啓示、金村昌 徳、田辺晃子、大道正英
    • Organizer
      第50回日本婦人科腫瘍学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 組織特異性を示すエストロゲンレセプターの制御機構と臨床応用2010

    • Author(s)
      寺井義人
    • Organizer
      第51回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      秋葉原コンベンションホール
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi