| Project/Area Number |
22592299
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OMATA Kazuhiko 日本歯科大学, 生命歯学部, 非常勤講師 (00434142)
HASHIMOTO Yoshiya 大阪歯科大学, 歯学部, 講師 (20228430)
SATOH Tazuko 日本歯科大学, 生命歯学部, 教授 (40095138)
YAMAZAKI Atsusi 早稲田大学, 理工学術院, 教授 (70200649)
ONO Tadao 早稲田大学, 理工学術院, 教授 (90160580)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯科矯正学 / 矯正用ミニスクリュー / 水熱酸化処理 / 酸化チタン膜 / ナノアパタイト層 / FGF-2 / セミインテグレーション / チタン / 酸化処理 / 抗酸化度 |
|---|
| Research Abstract |
In this study, we have developed two surface modifications of titanium alloy that improves its biofunctional activity. The surface of a Ti-6Al-4V disk was modified by applying 3% H2O2 hydrothermal treatment using an autoclave. A nanostructured porous network TiO2 was observed on the treated surface. Furthermore, the TiO2 titan disks were immersed in the supersaturated calcium phosphate solution to formed nano-apatite layer. We evaluated the surface analysis and bioactivities for FGF2 coated modified surfaces. As the results, significantly higher cell proliferation and celldifferentiation were exhibited, and enhanced biofunctional activity.
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