Individualized treatment of lung cancer based on the resistant mutation in EGFR gene from circulating tumor cells
| Project/Area Number |
22790746
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
INOUE Akira 東北大学, 病院, 特任准教授 (70361087)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | EGFR / 個別化治療 / 循環腫瘍細胞 / EGFRチロシンキナーゼ阻害剤 / EGFR遺伝子変異 / PNA-LNA PCRクランプ法 |
|---|
| Research Abstract |
Prospective study of individualized treatment for lung cancer resistant to epidermal growth factor receptor tyrosine kinase based on the T790M resistant mutation status detected from DNA of circulating tumor cells (CTC) was conducted. At the point when 6 enrolled patients were analyzed, it was revealed that the positive rate of CTC was quite lower than expected and that obtained DNA of CTC was too small to detect the T790M mutation. Thus the study was terminated halfway.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Quality of Life with Gefitinib in Patients with EGFR-Mutated Non-Small Cell Lung Cancer : Quality of Life Analysis of North East Japan Study Group 002 Trial2012
Author(s)
Oizumi S, Kobayashi K, Inoue A, Maemondo M, Sugawara S, Yoshizawa H, Isobe H, Harada M, Kinoshita I, Okinaga S, Kato T, Harada T, Gemma A, Saijo Y, Yokomizo Y, Morita S, Hagiwara K, Nukiwa T.
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Journal Title
Oncologist
Volume: 17
Issue: 6
Pages: 863-70
DOI
Related Report
Peer Reviewed
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[Journal Article]2012
Author(s)
Soda M, Isobe K, Inoue A, Maemondo M,Oizumi S, Fujita Y, Gemma A, Yamashita Y,Ueno T, Takeuchi K, Choi YL, Miyazawa H,Tanaka T, Hagiwara K, Mano H
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Journal Title
Clin Cancer Res
Volume: 18
Issue: 20
Pages: 5682-5689
DOI
Related Report
Peer Reviewed
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[Journal Article] Low-dose gefitinib treatment for patients with advanced non-small cell lung cancer harboring sensitive epidermal growth factor receptor mutations2011
Author(s)
Satoh H, Inoue A, Kobayashi K, Maemondo M, Oizumi S, Isobe H, Gemma A, Saijo Y, Yoshizawa H, Hagiwara K, Nukiwa T
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Journal Title
J Thorac Oncol
Volume: 6(8)
Issue: 8
Pages: 1413-7
DOI
Related Report
Peer Reviewed
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[Presentation] EGFR2012
Author(s)
井上彰
Organizer
第38回肺癌診断会シンポジウム2
Place of Presentation
越後湯沢
Year and Date
2012-06-23
Related Report
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[Presentation] 分子標的治療2012
Author(s)
井上彰
Organizer
第29回日本呼吸器外科学会総会教育講演
Place of Presentation
秋田
Year and Date
2012-05-17
Related Report
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