| Budget Amount *help |
¥214,760,000 (Direct Cost: ¥165,200,000、Indirect Cost: ¥49,560,000)
Fiscal Year 2015: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2014: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2013: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2012: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2011: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
|
|---|
| Outline of Final Research Achievements |
It has been well established that the autonomic system plays a major role in the pathogenesis of heart failure. Previous studies indicated that heart failure increases with ageing. We hypothesized that the age related loss of baroreflex function predisposes subjects to volume intolerance and leads to heart failure. We demonstrated in animal studies that the lack of baroreflex function makes subjects extremely sensitive to volume overload and predisposes to pulmonary edema via the increases in stressed blood volume and rightward shift of the pressure-diuresis curve. The artificial bionic baroreflex system, which electrically stimulates the baroreceptor afferent nerve in response to changes in arterial pressure, perfectly restores normal baroreflex function, thereby volume tolerance. We conclude that the bionic baroreflex system may serve as a new tool in the management of refractory heart failure including heart failure with preserved ejection fraction.
|
