| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
Large difference in symptoms, treatment response, and prognosis between patients with schizophrenia is assumed to be partly caused by difference in genome architecture. Recent genome analyses revealed important role of de novo mutation in sporadic cases. In familial cases, however, such breakthrough has not been discovered. Past studies indicate responsible locus in the short arm of chromosome 1 p in Japanese familial schizophrenia. To clarify path-etiology of Japanese familial schizophrenia, we screened the linkage region in the probands using next-generation sequencing and found the CELSR2 gene as a potential responsible gene of Japanese familial schizophrenia.
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