Diagnostic classification of pathophysiology of schizophrenia utilizing genomic information
Project/Area Number |
23390285
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | University of Tsukuba |
Principal Investigator |
ARINAMI TADAO 筑波大学, 医学医療系, 教授 (10212648)
|
Co-Investigator(Kenkyū-buntansha) |
IIJIMA Yoshimi 筑波大学, 医学医療系, 助教 (70574648)
|
Co-Investigator(Renkei-kenkyūsha) |
INADA Toshiya (財)神経研究所, 副所長 (00184721)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 臨床精神分子遺伝学 / 統合失調症 / エクソーム / 次世代シークエンサー / ゲノム / 脳神経疾患 / 遺伝学 / 薬剤応答性 |
Research Abstract |
Large difference in symptoms, treatment response, and prognosis between patients with schizophrenia is assumed to be partly caused by difference in genome architecture. Recent genome analyses revealed important role of de novo mutation in sporadic cases. In familial cases, however, such breakthrough has not been discovered. Past studies indicate responsible locus in the short arm of chromosome 1 p in Japanese familial schizophrenia. To clarify path-etiology of Japanese familial schizophrenia, we screened the linkage region in the probands using next-generation sequencing and found the CELSR2 gene as a potential responsible gene of Japanese familial schizophrenia.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia2013
Author(s)
Tanaka S, Syu A, Ishiguro H, Inada T, Horiuchi Y, Ishikawa M, Koga M, Noguchi E, Ozaki N, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T
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Journal Title
Pharmacogenomics J
Volume: 13(1)
Pages: 27-34
Related Report
Peer Reviewed
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[Journal Article] Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia.2013
Author(s)
Watanabe Y, Iijima Y, Egawa J, Nunokawa A, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Sasaki T, Ozaki N, Hashimoto R, Shibuya M, Igeta H, Someya T.
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Journal Title
Schizophrenia Research
Volume: 150
Pages: 596-597
Related Report
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[Journal Article] DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia2013
Author(s)
Tanaka S, Syu A, Ishiguro H, Inada T, Horiuchi Y, Ishikawa M, Koga M, Noguchi E, Ozaki N, Someya T, Kakita A, Takahashi H, Nawa H,Arinami T
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Journal Title
Pharmacogenomics J
Volume: 13(1)
Issue: 1
Pages: 27-34
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of SNPs linked to increased expression of SLC1A1 with schizophrenia2012
Author(s)
Horiuchi Y, Iida S, Koga M, Ishiguro H, Iijima Y, Inada T, Watanabe Y, Someya T, Ujike H, Iwata N, Ozaki N, Kunugi H, T ochigi M, Itokawa M, Arai M, Niizato K, Iritani S, Kakita A, Takahashi H, Nawa H, Arinami T
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B(1)
Pages: 30-7
Related Report
Peer Reviewed
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[Journal Article] Association of SNPs linked to increased expression of SLC1A1 with schizophrenia2012
Author(s)
Horiuchi Y, Iida S, Koga M, Ishiguro H, Iijima Y, Inada T, Watanabe Y, Someya T, Ujike H, Iwata N, Ozaki N, Kunugi H, Tochigi M, Itokawa M, Arai M, Niizato K, Iritani S, Kakita A, Takahashi H, Nawa H, Arinami T
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B(1)
Issue: 1
Pages: 30-37
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of SNPs linked to increased expression of SLC1A1 with schizophrenia2012
Author(s)
Horiuchi Y, Iida S, Koga M, Ishiguro H, Iijima Y, Inada T, Watanabe Y, Someya T, Ujike H, Iwata N, Ozaki N, Kunugi H, Tochigi M, Itokawa M, Arai M, Niizato K, Iritani S, Kakita A, Takahashi H, Nawa H, Arinami T
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Journal Title
American Journal of Medical Genetics
Volume: 159B
Pages: 30-37
Related Report
Peer Reviewed
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[Journal Article] Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia2011
Author(s)
Deng X, Takaki H, Wang L, Kuroki T, Nakahara T, Hashimoto K, Ninomiya H, Arinami T, Inada T, Ujike H, Itokawa M, Tochigi M, Watanabe Y, Someya T, Kunugi H, Iwata N, Ozaki N, Shibata H, Fukumaki Y
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Journal Title
American Journal of Medical Genetics
Volume: 156B
Pages: 850-858
Related Report
Peer Reviewed
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