Analysis of p53 72SNP in stress responce
| Project/Area Number |
23501267
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Tumor biology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
HABU Toshiyuki 京都大学, 放射線生物研究センター, 助教 (70346071)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | p53 / SNP / HPV / がん抑制遺伝子 / 遺伝子改変 / 外的要因ストレス / パピローマウイルス |
|---|
| Research Abstract |
Single nucleotide polymorphism(SNP) affect disease and stress responses. To address the relationship between SNP and stress response, p53 72SNP was introduced in human cell line using genetic recombination method. These cells showed the different responses under DNA damage agents although these cells have same genetic background. These results indicated that p53 SNP affect physiological output and these approach are useful for SNP study.
|
Report
(4 results)
Research Products
(31 results)
-
-
-
-
[Journal Article] The moyamoya disease susceptibility variant RNF213 1 R4810K induces genomic instability by mitotic abnormality2013
Author(s)
Hitomi T, Habu T, Kobayashi H, Okuda H, Harada HK, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A
-
Journal Title
Biochem. Biophys. Res. Commun
Volume: 439(4)
Pages: 419-426
Related Report
-
[Journal Article] Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients2013
Author(s)
Hitomi T, Habu T, Kobayashi H, Okuda H, Harada KH, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A
-
Journal Title
Biochem. Biophys. Res. Commun
Volume: 438(1)
Pages: 13-19
Related Report
-
-
-
[Journal Article] The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431)2013
Author(s)
Hitomi T, Habu T, Kobayashi H, Okuda H, Harada KH, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A
-
Journal Title
Biochem Biophys Res Commun.
Volume: 439(4)
Issue: 4
Pages: 419-426
DOI
Related Report
Peer Reviewed
-
[Journal Article] Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients.2013
Author(s)
Hitomi T, Habu T, Kobayashi H, Okuda H, Harada KH, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A.
-
Journal Title
Biochem Biophys Res Commun.
Volume: 438(1):
Issue: 1
Pages: 13-19
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Ablation of Rnf213 retards progression of diabetes in the Akita mouse2013
Author(s)
Kobayashi H, Yamazaki S, Takashima S, Liu W, Okuda H, Yan J, Fujii Y, Hitomi T, Harada KH, Habu T, Koizumi A
-
Journal Title
Biochem Biophys Res Commun
Volume: 432
Issue: 3
Pages: 519-525
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
