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Mechanism of the demyelination and regulation by the microglia in neuropathic pain

Research Project

Project/Area Number 23590727
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionFoundation for Biomedical Research and Innovation (2013)
Osaka Dental University (2011-2012)

Principal Investigator

MAEDA Mitsuyo  公益財団法人先端医療振興財団, 先端医療センター研究所再生医療研究部, 上席研究員 (40122080)

Co-Investigator(Kenkyū-buntansha) SUWA Fumihiko  大阪歯科大学, 歯学部, 教授 (30067178)
UEMURA Mamoru  大阪歯科大学, 歯学部, 助教 (30351472)
TAKEMURA Akimichi  大阪歯科大学, 歯学部, 准教授 (00155045)
TODA Isumi  大阪歯科大学, 歯学部, 講師 (20197891)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords神経因性疼痛 / LPA1 / ミクログリア / 脊髄後角 / 脱髄 / リゾホスファチジン酸
Research Abstract

We investigated the change of the lysophosphatidic acid receptor-1 (LPA-1) in the posterior horn of spinal cord known as a substance which participates in the pain and demyelination at the time of a neuropathic pain.The onset of LPA-1 mRNA was within postoperative 6 hour. LPA-1 immunoreactivity was observed in the cytoplasm of the oligodendrocyte, astrocyte of a posterior horn of spinal cord, and also, the protoplasmic membrane of the ganglion cell of a dorsal root ganglion, Schwann-cell, and myelin sheath. In injured side, the number of LPA-1 immune-positive cells increased at 3, 7days after injury. These LPA-1 immunopositive cells may be relevant to the onset of neuropathic pain.
Microglia were considered to be induces in activation, amplification and chronic pain through the ATP release by produced LPA at injured side.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2013 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Expression of single-stranded DNA and p53 in delayed neuronal death after transient ischemia in the gerbil hippocampus2013

    • Author(s)
      Maeda M, Takemura A, Toda I
    • Journal Title

      J Osaka Dent Univ

      Volume: 47 Pages: 31-40

    • NAID

      110009603276

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuro-muscular junctions2011

    • Author(s)
      Nagata K, Kiryu-Seo S, Maeda M, Yoshida K, Morita T, and Kiyama H
    • Journal Title

      J of Neuroscience

      Volume: 30

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nerve injury-activated microglia engulf myelinted axons in a P2Y12 signaling-dependent manner in the dorsal horn2010

    • Author(s)
      Maeda M, Tsusda M, Tozaki-Saitoh H, Inoue K, Kiyama H
    • Journal Title

      Glia

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 脳虚血モデルにおける変性神経細胞のサイクリンG1の局在とp53非依存性核内移行について2012

    • Author(s)
      前田光代, 武村明道, 戸田伊紀, ほか
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      奥羽大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Pericyte-derived neural stem/progenitor cells induced by transient cerebral ischemia2012

    • Author(s)
      Momota Y, Nakagomi T, Doi A, Maeda M, Shibata H, Taguchi A, Tsukamoto Y, Suwa F, Kotani J, Matsuyama T
    • Organizer
      The 35th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 脳虚血モデルにおける変性神経細胞のサイクリ ンG1の局在とp53非依存性核内移行について2012

    • Author(s)
      前田光代, 上村守, 戸田伊紀, 竹村明道, 諏訪文彦.
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      奥羽大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 運動神経切断後の再生軸索の形態学的マーカーとしてのVesicular acetylcholine transporter2011

    • Author(s)
      前田光代, 武村明道, 戸田伊紀, ほか
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岐阜県長良川国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 運動神経切除後の再生軸索の形態学的マーカーとしてのVesicular acetylcholine transporter2011

    • Author(s)
      前田光代
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜県長良川国際会議場
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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