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A prospective cohort study of factors contributing to accelerate the progress of fatty liver disease

Research Project

Project/Area Number 23590840
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Public health/Health science
Research InstitutionRadiation Effects Research Foundation

Principal Investigator

OHISHI Waka  公益財団法人放射線影響研究所, 広島臨床研究部, 部長代理 (20393423)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords脂肪性肝疾患 / 生活習慣 / 肝線維化 / 炎症 / インスリン抵抗性 / 酸化ストレス
Research Abstract

In the longitudinal follow-up cohort of atomic-bomb survivors, we conducted a cross-sectional study to investigate factors, which are associated with the prevalence and disease progression of fatty liver disease. Factors associated independently with the increased prevalence of NAFLD were obesity, diabetes, elevated ALT levels, declined adiponectin levels, and radiation exposure. In addition, factors such aging, obesity, smoking habit, diabetes, elevation of adiponectin or AST levels may be useful as indicators associated with the disease progression of NAFLD.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (42 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (23 results) Book (4 results) Remarks (3 results)

  • [Journal Article] Inverse associations between obesity indicators and thymic T-Cell production levels in aging atomic-bomb survivors2014

    • Author(s)
      Kengo Yoshida, Eiji Nakashima, Yoshiko Kubo, Mika Yamaoka, Junko Kajimura, Seishi Kyoizumi, Tomonori Hayashi, Waka Ohishi, Yoichiro Kusunoki
    • Journal Title

      PLoS One

      Volume: 9巻 Issue: 3 Pages: e91985-e91985

    • DOI

      10.1371/journal.pone.0091985

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum interleukin-6 associated with hepatocellular carcinoma risk: a nested case-control study2014

    • Author(s)
      Waka Ohishi, John B. Cologne, Saeko Fujiwara, Gen Suzuki, Tomonori Hayashi, Yasuharu Niwa, Masazumi Akahoshi, Keiko Ueda, Masataka Tsuge, Kazuaki Chayama
    • Journal Title

      International Journal of Cancer

      Volume: 134巻 Issue: 1 Pages: 154-163

    • DOI

      10.1002/ijc.28337

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum PAI-1 is a novel predictor for response to pegylated interferon-al pha-2b plus ribavirin therapy in chronic hepatitis C virus infection2012

    • Author(s)
      Miki D, Ohishi W, Ochi H, Hayes CN, Abe H, Tsuge M, Imamura M, Kamatani N, Nakamura Y, Chayama K
    • Journal Title

      J Viral Hepat

      Volume: 19 Issue: 2 Pages: 126-133

    • DOI

      10.1111/j.1365-2893.2011.01516.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 非B非C型肝癌のリスク因子2012

    • Author(s)
      大石和佳, 茶山一彰
    • Journal Title

      臨床消化器内科

      Volume: 27巻 Pages: 587-594

    • URL

      http://www.nmckk.jp//thesisDetail.php?category=CLGA&vol=27&no=5&d1=3&d2=8&d3=0&lang=ja

    • Related Report
      2013 Final Research Report
  • [Journal Article] 非B非C型肝癌のリスク因子2012

    • Author(s)
      大石和佳、茶山一彰
    • Journal Title

      臨床消化器内科

      Volume: 27 Pages: 587-594

    • Related Report
      2012 Research-status Report 2011 Research-status Report
  • [Journal Article] Treatment of chronic hepatitis B with nuoleos(t)ide analogues2011

    • Author(s)
      Ohishi W, Chayama K
    • Journal Title

      Hepatol Ees

      Volume: 42 Issue: 3 Pages: 219-25

    • DOI

      10.1111/j.1872-034x.2011.00921.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] *性、年齢、生活習慣関連因子、肝機能、肝臓線量、アディポネクチン値で調整.非B非C型肝癌リスクにおける放射線被曝と生活習慣の影響2011

    • Author(s)
      大石和佳, 藤原佐枝子, John B Cologne, 茶山一彰
    • Journal Title

      消化器内科

      Volume: 53巻 Pages: 453-458

    • URL

      http://ci.nii.ac.jp/naid/40019075100

    • Related Report
      2013 Final Research Report
  • [Journal Article] Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma2011

    • Author(s)
      Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, TsugeM, Chayama K
    • Journal Title

      Hepatology

      Volume: 53 Issue: 4 Pages: 1237-1245

    • DOI

      10.1002/hep.24207

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevention of hepatitis B virus reactivation in immunosuppressive therapy or chemotherapy2011

    • Author(s)
      Ohishi W, Chayama K
    • Journal Title

      Clin Exp Nephrol

      Volume: 15 Issue: 5 Pages: 634-640

    • DOI

      10.1007/s10157-011-0464-7

    • NAID

      10030340714

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis2011

    • Author(s)
      Yoshida K, Ohishi W, Nakashima E, Fujiwara S, Akahoshi M, Kasagi F, Chayama K, Hakoda M, Kyoizumi S, Nakachi K, Hayashi T, Kusunoki Y
    • Journal Title

      Hum Immunol

      Volume: 72 Issue: 10 Pages: 821-826

    • DOI

      10.1016/j.humimm.2011.05.029

    • NAID

      120006547414

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis2011

    • Author(s)
      Kengo Yoshida
    • Journal Title

      Hum Immunol

      Volume: 72 Pages: 821-826

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 非B非C型肝癌リスクにおける放射線被曝と生活習慣の影響2011

    • Author(s)
      大石和佳
    • Journal Title

      消化器内科

      Volume: 53 Pages: 453-458

    • Related Report
      2011 Research-status Report
  • [Presentation] 非アルコール性脂肪性肝疾患の有病率と病態に関連する因子の検討2014

    • Author(s)
      大石和佳
    • Organizer
      第50回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 原爆被爆者における血液細胞内活性酸素と年齢、放射線被曝及びIL-6R遺伝子多型との関連2013

    • Author(s)
      胡軼群
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2013-12-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of lifestyle, serum adiponectin and radiation on prevalence and progression of nonalcoholic fatty liver disease (NAFLD)2013

    • Author(s)
      Waka Ohishi
    • Organizer
      64th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2013-11-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患の肝繊維化における生活習慣とインスリン抵抗性の影響2013

    • Author(s)
      大石和佳
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-09
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-6レベルの上昇は肝細胞癌リスクの増加と関連する2013

    • Author(s)
      大石和佳
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-6レベルの上昇は肝細胞癌リスクの増加と関連する2013

    • Author(s)
      大石和佳、植田慶子、林 奉権、柘植雅貴、茶山一彰
    • Organizer
      第49回 日本肝臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Inflammatory markers are associated with risk of hepatocellular carcinoma : A nested case-control study2012

    • Author(s)
      Waka Ohishi
    • Organizer
      63rd Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston, USA
    • Year and Date
      2012-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 原爆被爆者の長期追跡コホートにおけるウイルス性肝炎研究2012

    • Author(s)
      大石和佳
    • Organizer
      第16回日本肝臓学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2012-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌リスクに寄与する炎症性マーカーの検討:コホート内症例対照研究2012

    • Author(s)
      大石和佳
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌リスクに寄与する炎症性マーカーの検討:コホート内症例対照研究2012

    • Author(s)
      大石和佳、藤原佐枝子、柘植雅貴、茶山一彰
    • Organizer
      第48回 日本肝臓学会総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Research-status Report
  • [Presentation] 原爆被爆者の長期追跡コホートにおけるウイルス性肝炎研究2012

    • Author(s)
      大石和佳、藤原佐枝子、茶山一彰
    • Organizer
      第16回 日本肝臓学会大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Interleukin-6 Levels Are Associated with Risk of Hepatocellular Carcinoma: A Nested Case-Control Study2012

    • Author(s)
      Ohishi W, Cologne JB, Fujiwara S, Hayashi T, Niwa Y, Ueda K, Tsuge M, Chayama K
    • Organizer
      63rd Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Immunological features associated with disease progression in persistent hepatitis C virus infection2011

    • Author(s)
      Waka Ohishi
    • Organizer
      62nd Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2011-11-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 慢性C型肝炎ウイルス感染の肝病態進行に関する免疫的特徴の検討2011

    • Author(s)
      大石和佳
    • Organizer
      第15回日本肝臓学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 非B非C型肝細胞癌のリスク因子:コホート内症例対照研究2011

    • Author(s)
      大石和佳
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 非B非C型肝細胞癌のリスク因子:コホート内症例対照研究2011

    • Author(s)
      大石和佳
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 慢性C型肝炎ウィルス感染の肝病態進行に関する免疫的特徴の検討2011

    • Author(s)
      大石和佳
    • Organizer
      第15回日本肝臓学会大会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Immunological features associated with disease progression in persistent hepatitis C virus infection2011

    • Author(s)
      Waka Ohishi
    • Organizer
      62nd Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Research-status Report
  • [Presentation] IL-6レベルの上昇は肝細胞癌リスクの増加と関連する

    • Author(s)
      大石和佳、Cologne JB、植田慶子、林 奉権、丹羽保晴、藤原佐枝子、柘植雅貴、茶山一彰
    • Organizer
      第49回 日本肝臓学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患の肝繊維化における生活習慣とインスリン抵抗性の影響

    • Author(s)
      大石和佳、植田慶子、立川佳美、中島栄二、山田美智子、高畑弥奈子、高橋郁乃、柘植雅貴、茶山一彰
    • Organizer
      第17回 日本肝臓学会大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of lifestyle, serum adiponectin and radiation on prevalence and progression of nonalcoholic fatty liver disease (NAFLD)

    • Author(s)
      Ohishi W, Ueda K, Tatsukawa Y, Nakashima E, Yamada M, Takahashi I, Tsuge M, Chayama K
    • Organizer
      64th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Walter E. Washington Convention Center (Washington DC, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患の有病率と病態に関連する因子の検討

    • Author(s)
      大石和佳、植田慶子、立川佳美、中島栄二、山田美智子、高畑弥奈子、高橋郁乃、柘植雅貴、茶山一彰
    • Organizer
      第50回 日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 原爆被爆者における血液細胞内活性酸素と年齢、放射線被曝及びIL-6R遺伝子多型との関連

    • Author(s)
      胡 軼群、大石和佳、吉田健吾、京泉誠之、楠 洋一郎、林 奉権
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2013 Annual Research Report
  • [Book] コホート研究からみたウイルス性肝炎の解明(原爆被爆者の長期追跡コホートにおけるウイルス性肝炎研究)2013

    • Author(s)
      大石和佳, 藤原佐枝子, 茶山一彰
    • Total Pages
      176
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Final Research Report
  • [Book] コホート研究からみたウイルス肝炎の解明 (原爆被爆者の長期追跡コホートにおけるウイルス性肝炎研究)2013

    • Author(s)
      大石和佳、茶山一彰
    • Total Pages
      176
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Annual Research Report
  • [Book] 新原爆放射線の人体影響 (A (2) d.肝がん)2012

    • Author(s)
      大石和佳、茶山一彰
    • Total Pages
      402
    • Publisher
      文光堂
    • Related Report
      2012 Research-status Report
  • [Book] 新原爆放射線の人体影響 (B (5) 肝疾患)2012

    • Author(s)
      大石和佳、茶山一彰
    • Total Pages
      402
    • Publisher
      文光堂
    • Related Report
      2012 Research-status Report
  • [Remarks] 研究計画書 6-08:エラストメーターを用いた原爆被爆者の肝弾性度調査、広島

    • URL

      http://www.rerf.or.jp/programs/rparchiv/rp06-08.htm

    • Related Report
      2013 Annual Research Report
  • [Remarks] 研究計画書 6-08:エラストメーターを用いた原爆被爆者の肝弾性度調査、広島

    • URL

      http://www.rerf.or.jp/programs/rparchiv/rp06-08.htm

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.rerf.jp/programs/rparchiv/rp06-08.htm

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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