Application of new generation PET to brain tumor treatment strategy

• Project/Area Number: 23591744
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: SHIGA Tohru 北海道大学, 医学(系)研究科(研究院), 准教授 (80374495)
• Co-Investigator(Kenkyū-buntansha): 西嶋 剣一 北海道大学, 医学(系)研究科(研究院), その他 (60364254) ; 寺坂 俊介 北海道大学, 医学(系)研究科(研究院), 准教授 (10447055)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 機能イメージング / 脳腫瘍 / 治療戦略 / 機能ｲﾒｰｼﾞﾝｸﾞ

Research Abstract

The purpose of this study was to reveal the usefulness of molecular imaging in strategy of brain tumor treatment. We used two technique for the purpose. One was to investigate relationships between molecular imaging and brain tumor pathology, another was to investigate the superiority of high spatial resolution and high energy resolution PET system in molecular imaging. We clarified that hypoxia imaging differentiated glioblastoma from other grade glioma and high spatial and energy resolution PET could produce high regression between FDG uptake and tumor proliferation.

Research Products

• [Journal Article] The diagnostic role of ¹⁸F-FDG PET for primary central nervous system lymphoma. (2014)
  • Author(s): Yamaguchi S, Hirata K, Kobayashi H, Shiga T, Manabe O, Kobayashi K, Motegi H, Terasaka S, Houkin K.
  • Journal Title: Ann Nucl Med Volume: In press
  • Peer Reviewed
• [Journal Article] Brain Regions Associated With Cognitive Impairment in Patients With Parkinson Disease : Quantitative Analysis of Cerebral Blood Flow Using 123I (2013)
  • Author(s): Hattori N
  • Journal Title: Clin Nucl Med Volume: 38(5) Issue: 5 Pages: 315-320
  • DOI: 10.1097/rlu.0b013e3182873511
  • Peer Reviewed
• [Journal Article] High reproducibility of tumor hypoxia evaluated by18F-fluoromisonidazole PET for head and neck cancer (2013)
  • Author(s): Okamoto S, Shiga T, Yasuda K, Ito YM, Magota K, Kasai K, Kuge Y, Shirato H, Tamaki N
  • Journal Title: J Nucl Med Volume: 54 Issue: 2 Pages: 201-207
  • DOI: 10.2967/jnumed.112.109330
  • Peer Reviewed
• [Journal Article] A novel PET scanner with semiconductor detectors may improve diagnostic accuracy in the metastatic survey of head and neck cancer patients (2013)
  • Author(s): Takei T
  • Journal Title: Ann Nucl Med Volume: 27(1) Issue: 1 Pages: 17-24
  • DOI: 10.1007/s12149-012-0654-8
  • Peer Reviewed
• [Journal Article] [18F]fluoromisonidazole and a new PET system with semiconductor detectors and a depth of interaction system for intensity modulated radiation therapy for nasopharyngeal cancer (2013)
  • Author(s): Yasuda K
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 85(1) Issue: 1 Pages: 142-147
  • DOI: 10.1016/j.ijrobp.2012.03.029
  • Peer Reviewed
• [Journal Article] F-18 -Fluoromisonidazole positron emission tomography may differentiate glioblastoma multiforme from less malignant gliomas (2012)
  • Author(s): Hirata K, Terasaka S, Shiga T, Hattori N, Magota K, Kobayashi H, Yamaguchi S, Houkin K, Tanaka S, Kuge Y, Tamaki N
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 39(5) Pages: 760-70
  • Peer Reviewed
• [Journal Article] (11)C-Methionine positron emission tomography may monitor the activity of encephalitis (2012)
  • Author(s): Hirata K
  • Journal Title: Acta Radiol Volume: 53(10) Issue: 10 Pages: 1155-1157
  • DOI: 10.1258/ar.2012.120382
  • Peer Reviewed
• [Journal Article] A patient who misidentified all surrounding persons as her family (2012)
  • Author(s): Sakurai K
  • Journal Title: Epilepsy Behav Volume: 25(2) Issue: 2 Pages: 162-165
  • DOI: 10.1016/j.yebeh.2012.06.025
  • Peer Reviewed
• [Journal Article] Predictors and clinical features of postoperative hyperperfusion after surgical revascularization for moyamoya disease: a serial single photon emission CT/positron emission tomography study (2012)
  • Author(s): Uchino H
  • Journal Title: Stroke Volume: 43(10) Pages: 2610-2616
  • Peer Reviewed
• [Presentation] DAT scanを含めた神経疾患における分子イメージング (2014)
  • Author(s): 志賀哲
  • Organizer: 日本神経学会北海道地方会
  • Place of Presentation: 北海道大学友会館フラテホール（札幌市）
  • Invited
• [Presentation] 低酸素イメージングの脳腫瘍への応用 (2013)
  • Author(s): 志賀哲
  • Organizer: 日本分子脳神経学会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2013-10-18
• [Presentation] 脳腫瘍患者におけるエネルギー窓の最適化 (2013)
  • Author(s): 志賀哲
  • Organizer: 日本核医学会総会
  • Place of Presentation: 福岡国際会議場(福岡市)
• [Presentation] 脳腫瘍患者における半導体PETの撮像エネルギー窓の最適化 (2013)
  • Author(s): 志賀哲
  • Organizer: 日本核医学会総会
  • Place of Presentation: 福岡国際会議場（福岡市）
• [Presentation] 低酸素イメージングの脳腫瘍への応用 (2013)
  • Author(s): 志賀哲
  • Organizer: 日本分子脳神経外科学会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] 半導体PET (2012)
  • Author(s): 志賀哲
  • Organizer: 第71回日本医学放射線学会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2012-04-14
• [Presentation] Optimization of energy windo wsetting of the semiconductor PET for cl inical FDG studies (2012)
  • Author(s): Shiga T
  • Organizer: SNM 2012 Annual meeting
  • Place of Presentation: Miami Beach Convention center(USA)
• [Presentation] 半導体PET (2012)
  • Author(s): 志賀哲
  • Organizer: 第71回日本医学放射線学会
  • Place of Presentation: パシフィコ横浜（神奈川県)
• [Presentation] Optimization of energy window setting of the semiconductor PET for clinical FDG studies (2012)
  • Author(s): Shiga T
  • Organizer: SNM 2012 Annual Meeting
  • Place of Presentation: Miami Beach Convention Center (USA)