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Systematic review for imaging of dementia

Research Project

Project/Area Number 23591760
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNagoya University

Principal Investigator

NIHASHI TAKASHI  名古屋大学, 医学部附属病院, 講師 (00426496)

Co-Investigator(Kenkyū-buntansha) TERASAWA Teruhiko  藤田保健衛生大学, 医学部, 准教授 (30399597)
ITO Kengo  独立行政法人長寿医療研究センター, 独立行政法人長寿医療研究センター・その他の部局, 部長 (70184653)
KAWAI Hisashi  名古屋大学, 医学部, 助教 (50378147)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords認知症 / バイオマーカー / 画像診断 / レビー小体型認知症 / アルツハイマー病 / 前頭側頭型認知症 / 軽度認知障害 / dementia / biomarker
Research Abstract

To quantitatively synthesize the test performance of imaging and cerebrospinal fluid (CSF) biomarkers for diagnosis of dementia, we conducted a systematic review and meta-analysis, with particular emphasis on comparative effectiveness.
We focused on differential diagnosis of dementia with Lewy bodies (DLB) and Frontotemporal lobar dementia (FTLD). In addition, diagnosis of mild cognitive impairment (MCI) is important theme, that is, prediction of Alzheimer disease (AD) converter and differential diagnosis of whether MCI or normal subject, or MCI or AD, etc. We searched PubMed (from January 2000 until December 2013) for English language publications, and totally reviewed 27986 publications. About the diagnosis of the MCI, we evaluated the evidence of functional MRI, diffusion tensor imaging, and perfusion imaging, using MRI, which had the potential to be innovative technology.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2013 Other

All Presentation (4 results)

  • [Presentation] アルツハイマー病(AD)とレビー小体型認知症(DLB)を鑑別するための画像およびCSFバイオマーカーの検査特性に関するメタアナリシス2013

    • Author(s)
      三島亜紀、二橋尚志
    • Organizer
      第85回東海核医学セミナー
    • Place of Presentation
      名古屋
    • Year and Date
      2013-12-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Imaging and cerebrospinal fluid (CSF) biomarkers for differentiating dementia with lewy body (DLB) from Alzheimer disease (AD): a meta-analysis of test performance2013

    • Author(s)
      Takashi Nihashi
    • Organizer
      Alzheimer's Association International Conference
    • Place of Presentation
      Boston USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Imaging and cerebrospinal fluid (CSF) biomarkers for differentiating dementia with lewy body (DLB) from Alzheimer disease (AD): a meta-analysis of test performance2013

    • Author(s)
      Takashi Nihashi, Teruhiko Terasawa, Aki Mishima, Yoshio Ando, Hisashi Kawai, Takashi Kato, Kengo Ito
    • Organizer
      Alzheimer's Association International Conference AAIC
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] アルツハイマー病(AD)とレビー小体型認知症(DLB)を鑑別するための画像およびCSFバイオマーカーの検査特性に関するメタアナリシス

    • Author(s)
      三島亜紀
    • Organizer
      第85回東海核医学セミナー
    • Place of Presentation
      名鉄ニューグランドホテル(名古屋市)
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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