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Evaluation of intravascular behavior and optimization of embolization microspheres for the paradigm shit of vascular embolotherapy

Research Project

Project/Area Number 23591819
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

OSUGA Keigo  大阪大学, 医学(系)研究科(研究院), 講師 (90332741)

Co-Investigator(Kenkyū-buntansha) MAEDA Noboru  大阪大学, 大学院医学系研究科, 助教 (00506488)
HIGASHIHARA Hiroki  大阪大学, 大学院医学系研究科, 助教 (90423186)
HIDAKA Kuniyuki  大阪大学, 医学部附属病院医療技術部放射線部, その他 (50437430)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords血管塞栓術 / 血管塞栓物質 / 球状ビーズ / 塞栓深度 / 血管ファントム
Research Abstract

We developed a vessel phantom with variable flow-velocity for simulating intravascular behavior of embolization microspheres. The in-vivo study using canine models suggested that optimal embolization endpoint was different among mechanical properties of microspheres in addition to the target organ and purpose of embolization. To achieve the total ischemia of parenchyma organs like the kidney, complete embolization using microspheres with high elasticity and high viscoelasticity seemed necessary. To minimize the ischemic damage of hollow organs like the small intestine, limited embolization with microspheres equal to or larger than 500 micron seemed appropriate.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2014 2013 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] 肝動脈塞栓療法における球状塞栓物質2013

    • Author(s)
      大須賀慶悟、前田登、東原大樹、他
    • Journal Title

      IVR学会誌2

      Volume: 28(4) Pages: 427-435

    • NAID

      130004707480

    • Related Report
      2013 Final Research Report
  • [Journal Article] 肝動脈塞栓療法における球状塞栓物質2013

    • Author(s)
      大須賀慶悟、前田登、東原大樹、田中会秀、岸本健太郎、中村純寿、小野祐介、中澤哲郎、富山憲幸
    • Journal Title

      日本IVR学会誌

      Volume: 28 Pages: 427-435

    • NAID

      130004707480

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Elasticity and viscoelasticity of embolization microspheres2011

    • Author(s)
      Hidaka K., Moine L., Collin G., Labarre D., Louis Grossiord J., Huang N., Osuga K., Wada S., Laurent A.
    • Journal Title

      J Mech Behav Biomed Mater

      Volume: 4(8) Pages: 2161-2167

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 球状ビーズを用いたイヌ小腸に対する腸間膜動脈塞栓術の塞栓効果の実験的検討2014

    • Author(s)
      岸本健太郎、大須賀慶悟、他
    • Organizer
      第43回日本IVR学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2014-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝癌治療におけるTACEの洗練化~ビーズの時代を迎えて2013

    • Author(s)
      大須賀慶悟
    • Organizer
      第49回日本肝癌研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-07-12
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] ビーズの物性と血流が塞栓血管径に及ぼす影響2013

    • Author(s)
      日高国幸、中村匡徳、大須賀慶悟
    • Organizer
      第42回日本IVR学会総会
    • Place of Presentation
      軽井沢
    • Year and Date
      2013-05-16
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 球状ビーズを用いたイヌ小腸に対する腸間膜動脈塞栓術の塞栓効果の実験的検討

    • Author(s)
      岸本健太郎、大須賀慶悟、前田登、東良幸、林聡恵、堀由美子、中村純寿、田中会秀、小野祐介、東原大樹、森井英一、大橋文人、富山憲幸
    • Organizer
      第43回日本IVR学会総会
    • Place of Presentation
      奈良
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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