The development of novel therapy with microRNA in gastric cancer

• Project/Area Number: 23591931
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Okayama University
• Principal Investigator: TSUKUDA Kazunori 岡山大学, 大学病院, 講師 (20346430)
• Co-Investigator(Kenkyū-buntansha): TOYOOKA Shinichi 岡山大学, 医歯薬学総合研究科, 教授 (30397880) ; ASANO Hiroaki 岡山大学, 大学病院, 助教 (70534775)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 胃癌 / マイクロＲＮＡ / 遺伝子治療 / アデノウイルスベクター

Research Abstract

The genetic alteration of microRNA 34b/c in gastric cancers has been studied. The microRNA 34b/c is considered to work under p53, the tumor suppressor gene, and have tumor suppressor effects. The promoter region was highly methylated and the expression was suppressed in most gastric cancer cell lines. The similar methylation was also found in primary gastric cancer tissues of the patients. And gene transfection of mircroRNA 34b/c in the gastric cancer cells showed the suppression of tumor growth which insinuated that this microRNA would be useful for gene therapy to the gastric cancers.