| Project/Area Number |
23592216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AOYAMA Eriko 岡山大学, 大学院医歯薬学総合研究科, 助教 (10432650)
FURUMATSU Takayuki 岡山大学, 岡山大学病院, 助教 (20432651)
KUBOTA Satoshi 岡山大学, 大学院医歯薬学総合研究科, 准教授 (90221936)
OZAKI Toshifumi 岡山大学, 大学院医歯薬学総合研究科, 教授 (40294459)
TAKIGAWA Masaharu 岡山大学, 大学院医歯薬学総合研究科, 教授 (20112063)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | CCN2 / 変形性関節症 / メタボローム解析 / 軟骨再生 / 軟骨細胞 |
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| Research Abstract |
Functional analysis and potential clinical applications of CCN2 as a metabolic supporter in chondrocyte regeneration. The purpose of this study was to analyze the influence of connective tissue growth factor (CCN2) on overall metabolism in chondrocytes, especially energy production and a molecular basis related to the energy production. The result revealed that the absence of CCN2 caused the decrease in the amount of adenosine triphosphate (ATP) in chondrocytes and suppression of glycolysis. Also, CCN2 was shown to be a metabolic supporter in chondrocyte regeneration producing ATP. Furthermore, the effect of articular cartilage regeneration in an osteoarthritis (OA) model suggested future clinical application for osteoarthritis cartilage treatment.
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