| Project/Area Number |
23592996
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Toshizo 山口大学, 医学(系)研究科(研究院), 教授 (90034991)
SHIBA Sunnji 九州歯科大学, 歯学部, 准教授 (20285472)
YOSHIDA Mitsuhiro 九州歯科大学, 歯学部, 助教 (40364153)
HARANO Nozomu 九州歯科大学, 歯学部, 助教 (50423976)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 癌性疼痛 / 神経障害性疼痛 / グリア / 細胞再生 / NOS / propentofylline / 神経因性疼痛 / 神経栄養因子 |
|---|
| Research Abstract |
We tested it for the purpose of obtaining a basic finding for clinical application of the treatment by elucidation and neurotrophy factor instruction of the clinical condition mechanism of the intractable pain. As a result, by elucidation of the interaction of glia cells of the spinal nerre for neuropathic pain and cancer pain, we obtained the initial finding of the therapy by the neurotrophy factor instruction. Efficacy of the suppression of inhibition and the NO production of the NNDA receptor which was present in postsynaptic cells for algetic suppression was found for the neuropathic pain. Observed spontaneous pain and anorexia in the subcutaneous injection model of the eyes lower buccal region of the cancer cell for cancer pain, but is reduction and anorexia of the spontaneous pain by administration of adenosine reuptake inhibitor
|
