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2013 Fiscal Year Final Research Report

Reproduction and the function reconstruction of the nucleus tractus spinalis sensory nerve cell in region of face cancer pain and the neuropathic pain

Research Project

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Project/Area Number 23592996
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu Dental College

Principal Investigator

NAKANISHI Osamu  九州歯科大学, 歯学部, その他 (50137345)

Co-Investigator(Kenkyū-buntansha) ISHIKAWA Toshizo  山口大学, 医学(系)研究科(研究院), 教授 (90034991)
SHIBA Sunnji  九州歯科大学, 歯学部, 准教授 (20285472)
YOSHIDA Mitsuhiro  九州歯科大学, 歯学部, 助教 (40364153)
HARANO Nozomu  九州歯科大学, 歯学部, 助教 (50423976)
Project Period (FY) 2011 – 2013
Keywords癌性疼痛 / 神経障害性疼痛 / グリア / 細胞再生
Research Abstract

We tested it for the purpose of obtaining a basic finding for clinical application of the treatment by elucidation and neurotrophy factor instruction of the clinical condition mechanism of the intractable pain. As a result, by elucidation of the interaction of glia cells of the spinal nerre for neuropathic pain and cancer pain, we obtained the initial finding of the therapy by the neurotrophy factor instruction. Efficacy of the suppression of inhibition and the NO production of the NNDA receptor which was present in postsynaptic cells for algetic suppression was found for the neuropathic pain. Observed spontaneous pain and anorexia in the subcutaneous injection model of the eyes lower buccal region of the cancer cell for cancer pain, but is reduction and anorexia of the spontaneous pain by administration of adenosine reuptake inhibitor

  • Research Products

    (6 results)

All 2014 2013 2012

All Journal Article (4 results) Presentation (2 results)

  • [Journal Article] Can the neurovascular compression volume of the trigeminal nerve on magnetic resonance cisternography predict the success of local anesthetic block after initial treatment by the carbamazepine?2014

    • Author(s)
      Shiiba S, Tanaka T, Nakanishi O, Inenaga K, Morimoto Y
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol

      Volume: 117(1) Pages: e15-21

    • DOI

      10.1016/j.oooo.2012.03.029

  • [Journal Article] Endothelin receptor-mediated responses in trigeminal ganglion neurons2013

    • Author(s)
      Yamamoto T, Ono K, Nakanishi O, Inenaga K
    • Journal Title

      J Dent Res

      Volume: 92 Pages: 335-9

    • DOI

      10.1002/ijc.28193

  • [Journal Article] Distinct time courses of microglial and astrocytic hyperactivation and the glial contribution to pain hypersensitivity in a facial cancer model2012

    • Author(s)
      Sago T, Ono K, Nakanishi O, Inenaga K
    • Journal Title

      Brain Res

      Volume: 1457 Pages: 70-80

    • DOI

      10.1016/j.brainres.2012.03.039

  • [Journal Article] Cutaneous magnetic stimulation reduces rat chronic pain via activation of the supra-spinal descending pathway2012

    • Author(s)
      Shiiba S, Yamamoto S, Yasuda S, Nakanishi O, Ishikawa T
    • Journal Title

      Cell Mol Neurobiol

      Volume: 32(2) Pages: 245-53

    • DOI

      10.1007/s10571-011-9756-4

  • [Presentation] GABA-A受容体(Bicuculline)誘発アロデニアにおける脊髄神経−glia機構2013

    • Author(s)
      吉田充広、石川浩三、仲西修、石川敏三
    • Organizer
      日本歯科麻酔学会
    • Year and Date
      20131002-04
  • [Presentation] 4-Methylcatechol(4-MC),BDNF inducer, ameliorates Choronic Pain with Depression via. Prevention of trkB related Signaling2013

    • Author(s)
      Nakanishi O, Ishikawa T
    • Organizer
      European Federation of IASP
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2013-10-10

URL: 

Published: 2015-07-16  

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